Block copolymeric biotransport carriers as versatile vehicles for drug delivery.
Block copolymeric biotransport carriers as versatile vehicles for drug delivery.
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DOI：
10.1517/13543784.7.9.1453
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发表时间：
1998-09-01
影响因子：
6.1
通讯作者：
Kabanov, A V
中科院分区：
文献类型：
--
作者：
Alakhov, V Y;Kabanov, A V
本文综述了嵌段共聚体系在药物输送中的应用。两亲性嵌段共聚物是目前研究的热点，它的应用改变了各类药物的药理性能，引起了人们越来越多的关注。造成这种情况的两个主要原因是基于嵌段共聚的药物制剂高度倾向于自组装，以及嵌段共聚化学的灵活性，这使得载体可以精确地定制到几乎任何化学实体。这些特点和其他一些特点的结合使得有可能调整基于嵌段共聚的药物配方，以在它们的生物相互作用(生物运输)中实现最有益的平衡，这些系统控制药物从体内的去除和那些负责药物治疗活动的系统。主要考虑以下几个方面：制剂的物理性质在其药理性能中的作用。嵌段共聚物的化学和物理化学以及这些体系中的结构-功能关系。举例说明生物转运系统对药物在细胞内的转运和活性的影响，以及它们与各种药物在体内应用的一些结果。
This review describes block co-polymer-based systems that are used in drug delivery. The main focus is on amphiphilic block co-polymers, the application of which modifies the pharmacological performance of various classes of drugs and is attracting more and more attention. The two main reasons for this are the high tendency of block co-polymer-based drug formulations to self-assemble and the flexibility of block co-polymer chemistry, which allows precise tailoring of the carrier to virtually any chemical entity. The combination of these and some other features makes it possible to adjust block co-polymer-based drug formulations to achieve the most beneficial balance in their biological interactions (biotransport), with systems that control drug removal from the body and those that are responsible for drug therapeutic activity. The following major aspects are considered: The role of physical properties of formulations in their pharmacological performance. The chemistry and physico-chemistry of block co-polymers and structure-function relationships in these systems. Examples describing the effects of biotransport systems on drug transport and activity in cells and some results on their in vivo applications with various drugs.