PULMONARY HAZARDS OF SMOKING MARIJUANA AS COMPARED WITH TOBACCO
PULMONARY HAZARDS OF SMOKING MARIJUANA AS COMPARED WITH TOBACCO
复制标题
DOI：
10.1056/nejm198802113180603
复制
发表时间：
1988-02-11
影响因子：
158.5
通讯作者：
ROSE, JE
中科院分区：
文献类型：
--
作者：
WU, TC;TASHKIN, DP;ROSE, JE
为了比较吸食大麻和烟草对肺部的危害，我们量化了来自相似数量的大麻和烟草烟雾的不溶性颗粒（焦油）和一氧化碳对肺部的相对负担。这15名研究对象都是男性，同时吸大麻和烟草至少有5年的习惯。我们测量了每位受试者在吸烟前后的血液碳氧血红蛋白水平，以及吸入的焦油量和呼吸道中沉积的焦油量，这些焦油来自含0.004%或1.24% . delta .9-四氢大麻酚的单嘴烟草香烟（900至1200毫克）和大麻香烟（741至985毫克）。与吸烟相比，吸食大麻与血液中碳氧血红蛋白水平增加近五倍有关，吸入焦油量增加约三倍，呼吸道中吸入焦油的滞留量增加三分之一（P < 0.001）。吸食大麻和烟草的动态也有显著差异，其中大麻的吞吐量约为烟草的三分之二，吸入深度约为三分之一，屏气时间为烟草的四倍（P < 0.01）。吸食大麻过程中的吸烟动态和焦油的释放只受到四氢大麻酚百分比的轻微影响。我们得出的结论是，吸食大麻，无论四氢大麻酚含量如何，都会导致一氧化碳和焦油的呼吸负担大大高于吸食同等数量的烟草。
To compare the pulmonary hazards of smoking marijuana and tobacco, we quantified the relative burden to the lung of insoluble particulates (tar) and carbon monoxide from the smoke of similar quantities of marijuana and tobacco. The 15 subjects, all men, had smoked both marijuana and tobacco habitually for at least five years. We measured each subject''s blood carboxyhemoglobin level before and after smoking and the amount of tar inhaled and deposited in the respiratory tract from the smoke of single filter-tipped tobacco cigarettes (900 to 1200 mg) and marijuana cigarettes (741 to 985 mg) containing 0.004 percent or 1.24 percent .DELTA.9-tetrahydrocannabinol. As compared with smoking tobacco, smoking marijuana was associated with a nearly fivefold greater increment in the blood carboxyhemoglobin level, an approximately threefold increase in the amount of tar inhaled, and retention in the respiratory tract of one third more inhaled tar (P < 0.001). Significant differences were also noted in the dynamics of smoking marijuana and tobacco, among them an approximately two-thirds larger puff volume, a one-third greater depth of inhalation, and a fourfold longer breath-holding time with marijuana than with tobacco (P < 0.01). Smoking dynamics and the delivery of tar during marijuana smoking were only slightly influenced by the percentage of tetrahydrocannabinol. We conclude that smoking marijuana, regardless of tetrahydrocannabinol content, results in a substantially greater respiratory burden of carbon monoxide and tar than smoking a similar quantity of tobacco.