Association of 25-hydroxy-vitamin D levels with semen and hormonal parameters
Association of 25-hydroxy-vitamin D levels with semen and hormonal parameters
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DOI：
10.1038/aja.2012.77
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发表时间：
2012-11-01
影响因子：
2.9
通讯作者：
Carrell, Douglas T.
中科院分区：
文献类型：
--
作者：
Hammoud, Ahmad O.;Meikle, A. Wayne;Carrell, Douglas T.
维生素D水平与各种健康结果有关，包括生殖障碍。本研究的目的是探讨血清维生素D水平（25-羟基维生素D，或25 OHD）与精液和激素参数之间的关系。这是一项横断面研究，包括从普通人群中招募的170名健康男性进行精子发生研究。男性完成了一般和生殖健康问卷，并捐献了血液和精液样本。主要措施是激素（总睾酮和游离睾酮，性激素结合球蛋白，雌二醇，卵泡刺激素和促黄体生成素）和精液参数，调整（n=147）的年龄，体重指数（BMI），季节，酒精摄入量和吸烟，维生素D水平的类别，确定了先验。研究人群的平均年龄为29.0 ± 8.5岁，平均BMI为24.3 ± 3.2 kg m（-2）。平均25 OHD为34.1 +/- 15.06 ng ml（-1）。BMI与25 OHD呈负相关。与“20 ng ml（-1）”男性相比，“25 OHD>= 50 ng ml（-1）”男性的精子浓度、精子前向运动力、精子形态和前向运动精子总数均较低
Vitamin D levels have been linked to various health outcomes including reproductive disorders. The purpose of this study was to explore the association between serum vitamin D level (25-hydroxy-vitamin D, or 25OHD) and semen and hormonal parameters. This is a cross-sectional study that included 170 healthy men recruited for the study of spermatogenesis from the general population. Men completed general and reproductive health questionnaires, and donated blood and semen samples. The main measures were hormonal (total and free testosterone, sex hormone-binding globulin, estradiol, follicle-stimulating hormone and luteinizing hormone) and semen parameters, adjusted (n=147) for age, body mass index (BMI), season, alcohol intake and smoking, in relation to categories of vitamin D levels, determined a priori. The mean age of the study population was 29.0 +/- 8.5 years and mean BMI was 24.3 +/- 3.2 kg m(-2). The mean 25OHD was 34.1 +/- 15.06 ng ml(-1). BMI showed a negative association with 25OHD. Sperm concentration, sperm progressive motility, sperm morphology, and total progressively motile sperm count were lower in men with '25OHD >= 50 ng ml(-1)' when compared to men with '20 ng ml(-1)