In vitro colonization ability of human colon mucosa by exogenous Lactobacillus strains.
In vitro colonization ability of human colon mucosa by exogenous Lactobacillus strains.
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外源乳杆菌菌株对人结肠粘膜的体外定植能力。
DOI：
10.1111/j.1574-6968.1995.tb07767.x
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发表时间：
1995
影响因子：
2.1
通讯作者：
J. Nicolas
中科院分区：
文献类型：
--
作者：
L. Sarem;F. Sarem;L. Marchal;J. Nicolas
我们在人类结肠上皮培养模型中测试了五种乳杆菌菌株的体外定植能力。在四种乳杆菌菌株存在下，出现不同程度的阳性定植。我们发现干酪乳杆菌 GG 和嗜酸乳杆菌 NCFB 1748 诱导中间定植。这两种菌株已被其他人广泛研究，据报道对人类有益。我们的研究中使用人体肠道组织部分重建了人体上皮与粘液层的复杂结构特异性，更接近地模拟了体内情况。
We have tested five Lactobacillus strains for their in vitro colonization ability in a human colon epithelium culture model. Positive colonization occurred in different degrees in the presence of four Lactobacillus strains. We have found that L. casei GG and L. acidophilus NCFB 1748 induce an intermediate colonization. These two strains, largely investigated by others, have been reported to be beneficial to humans. The use of human intestinal tissue in our study partially reconstitutes the complex architectural specificity of human epithelium with the mucus layer and more closely simulates the in vivo situation.