Imaging characteristics and prognostic values of hepatic epithelioid hemangioendothelioma on18F-FDG PET/CT
Imaging characteristics and prognostic values of hepatic epithelioid hemangioendothelioma on18F-FDG PET/CT
复制标题
肝上皮样血管内皮瘤~(18)F-FDG PET/CT影像学特征及预后价值
DOI：
10.1007/s10238-020-00653-0
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发表时间：
2020-08-14
影响因子：
4.6
通讯作者：
Shi, Hongcheng
中科院分区：
文献类型：
--
作者：
Wang, Weimin;Liu, Guobing;Shi, Hongcheng
肝上皮样血管内皮瘤（HEHE）是一种低中度恶性间叶质肿瘤。 2-[18F]氟-2-脱氧-D-葡萄糖 (F-18-FDG) 正电子发射断层扫描/计算机断层扫描 (PET/CT) 对 HEHE 患者的诊断和预后价值尚未得到充分验证。测量并分析20例HEHE患者的生存结局（包括总生存期[OS]和无进展生存期[PFS]）、病灶特征和半定量参数，包括最大标准化摄取值（SUVmax）、SUV峰值（SUVpeak）、总病灶糖酵解（TLG）和代谢肿瘤体积（MTV）（18）F-FDG PET/CT。共检出肝脏病灶310个（排除3例弥漫型病灶）。大多数病灶延迟成像时的 SUV(max) 高于早期成像 (P = 0.013)。与仅肝脏受累的患者相比，多器官受累的患者死亡率更高（P = 0.022），进展率更高（P = 0.020），OS更短（P = 0.011），病变SUVmax（P = 0.048）和TLG（P = 0.033）更大。在预测 OS 时，受试者工作特征 (ROC) 曲线分析的 SUVmax、SUVpeak、TLG 和 MTV 曲线下面积 (AUC) 分别为 0.960、0.949、0.980 和 0.960（P 分别 = 0.005、0.008、0.001 和 0.024）。对于预测 PFS，AUC 分别为 0.791、0.824、0.857 和 0.813（P = 0.036、0.019、0.010 和 0.024）。双时间点成像可以提高病变的可检测性。多器官受累的患者预后较差。病灶SUVmax、SUVpeak、TLG、MTV越高，患者预后越差。
Hepatic epithelioid hemangioendothelioma (HEHE) is a low-to-intermediate-grade malignant mesenchymal tumor. The diagnostic and prognostic values of 2-[18F] fluoro-2-deoxy-D-glucose (F-18-FDG) positron emission tomography/computed tomography (PET/CT) to patients with HEHE have not been fully validated. Patient survival outcomes (including overall survival [OS] and progression-free survival [PFS]), lesions characteristics and semi-quantitative parameters, in terms of maximum standardized uptake value (SUVmax), peak SUV (SUVpeak), total lesion glycolysis (TLG) and metabolic tumor volume (MTV) on(18)F-FDG PET/CT of 20 cases with HEHE were measured and analyzed. A total of 310 liver lesions were detected (excluding the diffuse-type lesions in 3 cases). Most lesions had higher SUV(max)in delayed imaging than in early imaging (P = 0.013). Patients with multiple organs involved had higher death rate (P = 0.022), higher progression rate (P = 0.020), shorter OS (P = 0.011), larger lesion SUVmax(P = 0.048) and TLG (P = 0.033) than those with only liver involved. The area under curves (AUCs) from the receiver operating characteristic (ROC) curve analysis were 0.960, 0.949, 0.980 and 0.960 for SUVmax,SUVpeak, TLG and MTV, respectively, in predicting OS (P = 0.005, 0.008, 0.001 and 0.024, respectively). For predicting PFS, the AUCs were 0.791, 0.824, 0.857 and 0.813 (P = 0.036, 0.019, 0.010 and 0.024), respectively. Dual-time-point imaging may improve lesions detectability. Patients with multiple organ involved had worse prognosis. The higher SUVmax, SUVpeak, TLG and MTV of lesions, the worse prognosis of patients were found.