Response of Cerebral Blood Flow and Blood Pressure to Dynamic Exercise: A Study Using PET
Response of Cerebral Blood Flow and Blood Pressure to Dynamic Exercise: A Study Using PET
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DOI：
10.1055/s-0043-123647
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发表时间：
2018-02-01
影响因子：
2.5
通讯作者：
Maehara, Taketoshi
中科院分区：
文献类型：
--
作者：
Hiura, Mikio;Nariai, Tadashi;Maehara, Taketoshi
动态运动引起血压和脑血流量的波动。本研究使用正电子发射断层扫描（PET）研究了骑自行车运动和运动后低血压（PEH）期间BP和CBF的反应。使用氧-15-标记水（HO）和PET测量11名人类受试者在休息时（休息）、运动开始时（Ex 1）、运动后期（Ex 2）和PEH期间的CBF。与静息时相比，Ex 1时总体CBF显著增加13%，但Ex 2和PEH期间无变化。与静息时相比，Ex 1时小脑蚓部、双侧下肢感觉运动皮质（M1和S1（腿））、岛叶皮质和脑干的局部CBF（rCBF）增加（2042%），Ex 2时仅小脑蚓部、M1（腿）和S1（腿）的局部CBF增加（2831%）。PEH时小脑、颞回、梨状叶、丘脑和脑桥的rCBF较静息时降低81.3%。显示运动和PEH期间rCBF和平均BP之间相关性的区域与中枢自主神经网络一致，包括脑干、小脑和下丘脑（R-2=0.25-0.64）。目前的研究表明，更高的大脑区域通过脑干中的反射中心协调，以调节心血管对运动的反应。
Dynamic exercise elicits fluctuations in blood pressure (BP) and cerebral blood flow (CBF). This study investigated responses in BP and CBF during cycling exercise and post-exercise hypotension (PEH) using positron emission tomography (PET). CBF was measured using oxygen-15-labeled water (HO) and PET in 11 human subjects at rest (Rest), at the onset of exercise (Ex1), later in the exercise (Ex2), and during PEH. Global CBF significantly increased by 13% at Ex1 compared with Rest, but was unchanged at Ex2 and during PEH. Compared with at Rest, regional CBF (rCBF) increased at Ex1 (2042%) in the cerebellar vermis, sensorimotor cortex for the bilateral legs (M1 and S1(Leg)), insular cortex and brain stem, but increased at Ex2 (2831%) only in the vermis and M1(Leg) and S1(Leg) . During PEH, rCBF decreased compared with Rest (813%) in the cerebellum, temporal gyrus, piriform lobe, thalamus and pons. The areas showing correlations between rCBF and mean BP during exercise and PEH were consistent with the central autonomic network, including the brain stem, cerebellum, and hypothalamus (R-2=0.25-0.64). The present study suggests that higher brain regions are coordinated through reflex centers in the brain stem in order to regulate the cardiovascular response to exercise.