EFFECT OF LESION LOCATION WITHIN THE MEDIAL PREOPTIC-ANTERIOR HYPOTHALAMIC CONTINUUM ON MATERNAL AND MALE SEXUAL BEHAVIORS IN FEMALE RATS
EFFECT OF LESION LOCATION WITHIN THE MEDIAL PREOPTIC-ANTERIOR HYPOTHALAMIC CONTINUUM ON MATERNAL AND MALE SEXUAL BEHAVIORS IN FEMALE RATS
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DOI：
10.1037/0735-7044.98.4.703
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发表时间：
1984-01-01
影响因子：
1.9
通讯作者：
BROOKS, PJ
中科院分区：
文献类型：
--
作者：
GRAY, P;BROOKS, PJ
已知大鼠内侧视前-下丘脑前部连续体（MPOA-AH）的病变会破坏母性行为和雄性性行为。为了验证这两种行为在MPOA-AH中涉及不同神经系统的假设，我们在雌性致化、睾酮处理的雌性大鼠的MPOA-AH的前后不同位置做了小的双侧病变，并评估这些病变对雌性和雄性性行为的影响。以MPOA为中心的病变破坏了母鼠的行为（找回幼崽、筑巢和哺乳），MPOA前部病变比MPOA后部病变更有效（找回幼崽和筑巢）。以AH为中心的病变对母亲的行为影响很小或没有影响。男性的性行为（性交）被MPOA或AH的病变严重破坏，其中吻侧AH的病变最有效。
Lesions of the medial preoptic-anterior hypothalamic continuum (MPOA-AH) are known to disrupt both maternal behavior and male sexual behavior in the rat. To test the hypothesis that the 2 behaviors involve different neural systems in the MPOA-AH, small bilateral lesions were made in different anterior-posterior locations in the MPOA-AH of maternal-sensitized, testosterone-treated female rats, and the effects of these lesions on maternal and male sexual behaviors were assessed. Lesions centering in the MPOA disrupted maternal behavior (pup retrieval, nest building, and nursing), with anterior MPOA lesions being more effective (on pup retrieval and nest building) than posterior MPOA lesions. Lesions centering in the AH had little or no effect on maternal behavior. Male sexual behavior (mounting) was strongly disrupted by lesions in either the MPOA or the AH, with lesions in the rostral AH being most effective.