Collagen type IX from human cartilage: A structural profile of intermolecular cross-linking sites
Collagen type IX from human cartilage: A structural profile of intermolecular cross-linking sites
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DOI：
10.1042/bj3140327
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发表时间：
1996-02-15
影响因子：
4.1
通讯作者：
Eyre, DR
中科院分区：
文献类型：
--
作者：
Diab, M;Wu, JJ;Eyre, DR
IX型胶原，软骨的少量胶原成分。已知与鸡和牛软骨中的II型胶原原纤维相关并共价交联。IX型胶原分子也被证明在牛软骨中彼此形成共价交联。在本研究中，我们通过结构分析和交联位点的定位证明，在人类软骨中，IX型胶原蛋白与II型胶原蛋白和IX型胶原蛋白的其他分子共价交联。我们还提出证据表明，如果IX型胶原蛋白的蛋白聚糖形式存在于人软骨中，它只能是基质的一小部分，类似于牛软骨的发现。
Type IX collagen, a quantitatively minor collagenous component of cartilage. is known to be associated with and covalently cross-linked to type II collagen fibrils in chick and bovine cartilage. Type IX collagen molecules have also been shown to form covalent cross-links with each other in bovine cartilage. In the present study we demonstrate by structural analysis and location of cross-linking sites that, in human cartilage, type IX collagen is covalently cross-linked to type II collagen and to other molecules of type IX collagen. We also present evidence that, if the proteoglycan form of type IX collagen is present in human cartilage, it can only be a minor component of the matrix, similar to findings with bovine cartilage.