Functional Genomics and CRISPR Applied to Cardiovascular Research and Medicine.
Functional Genomics and CRISPR Applied to Cardiovascular Research and Medicine.
复制标题
DOI：
10.1161/atvbaha.119.312579
复制
发表时间：
2019-08
期刊：
影响因子：
--
通讯作者：
Fang Li;Jianting Shi;Hong S. Lu;Hanrui Zhang
中科院分区：
文献类型：
--
作者：
Fang Li;Jianting Shi;Hong S. Lu;Hanrui Zhang
The growing knowledge of the human genome sequence has spurred the interest in functional genomics. 1 Functional genomics aims to understand the complex relationship between genotype and phenotype. Using high-throughput methods, functional genomics has expanded biomedical science beyond reductionist approaches and strive to gain an unbiased view of the regulation of gene transcription, translation, and protein-protein interactions on a genomic scale. A more focused functional genomics approach determines the functional impact of genomic variation, such as mutations and polymorphisms associated with complex traits and diseases. The endeavor of functional genomics is fueling an explosion of new insights into novel biology and therapeutic strategies. 2
