The Medicinal Use of Cannabis and Cannabinoids-An International Cross-Sectional Survey on Administration Forms
The Medicinal Use of Cannabis and Cannabinoids-An International Cross-Sectional Survey on Administration Forms
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DOI：
10.1080/02791072.2013.805976
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发表时间：
2013-07-01
影响因子：
2.8
通讯作者：
Grotenhermen, Franjo
中科院分区：
文献类型：
--
作者：
Hazekamp, Arno;Ware, Mark A.;Grotenhermen, Franjo
大麻素，包括四氢大麻酚和大麻二酚，是大麻植物中最重要的活性成分。近年来，在许多国家，以大麻素为基础的药物（CBMs）越来越多地作为药品和草药大麻（大麻）提供给患者。虽然似乎需要多种基于大麻素的治疗产品，特别是用于慢性疾病的症状改善，但不同CBMs的治疗效果仅在少数临床研究中进行了直接比较。这里提出的调查是由国际大麻素药物协会（IACM）进行的，旨在通过询问使用大麻或大麻素的患者详细问题，了解他们使用不同摄入方法的经历，从而有助于了解以大麻素为基础的医学。该调查由来自31个国家的953名参与者完成，这是迄今为止对大麻素类药物的各种使用者进行的最大的国际调查。一般来说，草药非药物类CBMs比含有大麻素的药物产品获得更高的评价分数。然而，报告使用过药品的患者数量很少，限制了关于偏好的结论。然而，报告的数据可能有助于进一步开发基于大麻和单一大麻素的安全有效药物。
Cannabinoids, including tetrahydrocannabinol and cannabidiol, are the most important active constituents of the cannabis plant. Over recent years, cannabinoid-based medicines (CBMs) have become increasingly available to patients in many countries, both as pharmaceutical products and as herbal cannabis (marijuana). While there seems to be a demand for multiple cannabinoid-based therapeutic products, specifically for symptomatic amelioration in chronic diseases, therapeutic effects of different CBMs have only been directly compared in a few clinical studies. The survey presented here was performed by the International Association for Cannabinoid Medicines (IACM), and is meant to contribute to the understanding of cannabinoid-based medicine by asking patients who used cannabis or cannabinoids detailed questions about their experiences with different methods of intake. The survey was completed by 953 participants from 31 countries, making this the largest international survey on a wide variety of users of cannabinoid-based medicine performed so far. In general, herbal non-pharmaceutical CBMs received higher appreciation scores by participants than pharmaceutical products containing cannabinoids. However, the number of patients who reported experience with pharmaceutical products was low, limiting conclusions on preferences. Nevertheless, the reported data may be useful for further development of safe and effective medications based on cannabis and single cannabinoids.