Maternal cytokine levels during pregnancy and adult psychosis
Maternal cytokine levels during pregnancy and adult psychosis
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DOI：
10.1006/brbi.2001.0644
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发表时间：
2001-12-01
影响因子：
15.1
通讯作者：
Yolken, RH
中科院分区：
文献类型：
--
作者：
Buka, SL;Tsuang, MT;Yolken, RH
我们研究了妊娠晚期母体细胞因子水平与其后代成年精神分裂症和其他精神病的后续发展之间的关系。样本包括 27 名患有精神分裂症和其他精神疾病的成年人的母亲，以及来自围产期合作项目普罗维登斯队列的 50 名匹配的未受影响对照者。通过酶免疫测定法分析血清样本中的白细胞介素 1 β (IL-1 β)、白细胞介素 2 (IL-2)、白细胞介素 6 (IL-6)、白细胞介素 8 (IL-8) 和肿瘤坏死因子 α (TNF-α)。在病例系列中，母体 TNF-α 水平显着升高（t=2.22，p=0.04），有证据表明精神病的几率随着细胞因子水平的升高而增加。我们没有发现病例母亲和对照母亲的血清 IL-1、IL-2、IL-6 或 IL-8 水平存在显着差异。这些数据支持之前的临床研究，报告称孕期母亲感染是后代精神病的潜在危险因素。 (C) 2001 年爱思唯尔科学。
We investigated levels of maternal cytokines in late pregnancy in relation to the subsequent development of adult schizophrenia and other psychoses in their offspring. The sample included the mothers of 27 adults with schizophrenia and other psychotic illnesses and 50 matched unaffected controls from the Providence cohort of the Collaborative Perinatal Project. Serum samples were analyzed for interleukin 1 beta (IL-1 beta), interleukin 2 (IL-2), interleukin 6 (IL-6), interleukin 8 (IL-8), and tumor necrosis factor alpha (TNF-alpha) by enzyme immunoassay. Maternal levels of TNF-alpha were significantly elevated among the case series (t=2.22, p=.04), with evidence of increasing odds of psychosis in relation to higher cytokine levels. We did not find significant differences between case and control mothers in the serum levels of IL-1, IL-2, IL-6 or IL-8. These data support previous clinical investigations reporting maternal infections during pregnancy as a potential risk factor for psychotic illness among offspring. (C) 2001 Elsevier Science.