Electrophysiological correlates of stimulus-driven reorienting deficits after interference with right parietal cortex during a spatial attention task: a TMS-EEG study.
Electrophysiological correlates of stimulus-driven reorienting deficits after interference with right parietal cortex during a spatial attention task: a TMS-EEG study.
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DOI：
10.1162/jocn_a_00287
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发表时间：
2012-12
影响因子：
3.2
通讯作者：
Babiloni C
中科院分区：
文献类型：
--
作者：
Capotosto P;Corbetta M;Romani GL;Babiloni C
经颅磁刺激（TMS）干扰右侧顶内沟（IPS）的原因是破坏行为和脑电图（EEG）的内源性空间定向的节奏相关性之前，视觉目标呈现。在这里，我们结合联合收割机数据，从我们以前的研究，以检查是否右顶叶TMS在空间定向也损害刺激驱动的重新定向或有效地处理无人值守的刺激，即刺激以外的当前注意力的焦点。健康受试者（N=24）进行Posner空间线索任务，而他们的脑电图活动被监测。重复经颅磁刺激（rTMS）应用150毫秒（ms）的同时，一个中央箭头的介绍，引导空间注意力的位置即将到来的视觉目标。右IPS-rTMS受损的目标检测，特别是在无人看管的位置呈现的刺激，它也引起了调制的顶枕叶正ERP峰值在约480毫秒（P3）后目标的振幅。与Sham刺激相比，右侧IPS-rTMS后无人值守靶点的P3显著降低，而有人值守靶点的P3显著增加。左侧IPS刺激获得了类似的效果，尽管受试者人数较少。我们的结论是，在正确的IPS的预期过程中断有长期的影响，持续在目标处理。P3递减可能反映了对决策后过程的干扰，这些决策后过程是刺激驱动的重新定向的一部分。右IPS是人类视觉中内源性空间定向和刺激驱动的重定向过程之间的功能相互作用的节点。
Transcranial magnetic stimulation (TMS) interference over right intraparietal sulcus (IPS) causally disrupts behaviorally and electroencephalographic (EEG) rhythmic correlates of endogenous spatial orienting prior to visual target presentation. Here we combine data from our previous studies to examine whether right parietal TMS during spatial orienting also impairs stimulus-driven re-orienting or the ability to efficiently process unattended stimuli, i.e. stimuli outside the current focus of attention. Healthy subjects (N=24) performed a Posner spatial cueing task while their EEG activity was being monitored. Repetitive TMS (rTMS) was applied for 150 milliseconds (ms) simultaneously to the presentation of a central arrow directing spatial attention to the location of an upcoming visual target. Right IPS-rTMS impaired target detection, especially for stimuli presented at unattended locations; it also caused a modulation of the amplitude of parieto-occipital positive ERPs peaking at about 480 ms (P3) post-target. The P3 significantly decreased for unattended targets, and significantly increased for attended targets after right IPS-rTMS as compared to Sham stimulation. Similar effects were obtained for left IPS stimulation albeit in a smaller group of subjects. We conclude that disruption of anticipatory processes in right IPS has prolonged effects that persist during target processing. The P3 decrement may reflect interference with post-decision processes that are part of stimulus-driven re-orienting. Right IPS is a node of functional interaction between endogenous spatial orienting and stimulus-driven re-orienting processes in human vision.
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DOI：
10.1523/jneurosci.1776-08.2008
发表时间：
2008-10-01
期刊：
The Journal of neuroscience : the official journal of the Society for Neuroscience
影响因子：
--
作者：
Bressler SL;Tang W;Sylvester CM;Shulman GL;Corbetta M
通讯作者：
Corbetta M
影响因子：
2.7
作者：
O'Donnell, BF;Swearer, JM;McCarley, RW
通讯作者：
McCarley, RW
DOI：
10.1016/0013-4694(96)95711-9
发表时间：
1996-09-01
期刊：
ELECTROENCEPHALOGRAPHY AND CLINICAL NEUROPHYSIOLOGY
影响因子：
--
作者：
Eimer, M
通讯作者：
Eimer, M
影响因子：
3.7
作者：
Akyuerek, Elkan G.;Leszczynski, Marcin;Schuboe, Anna
通讯作者：
Schuboe, Anna
DOI：
10.1073/pnas.0505785103
发表时间：
2006-02-21
影响因子：
11.1
作者：
Mazaheri, A;Jensen, O
通讯作者：
Jensen, O