SYNAPTIC REMODELING AND ASTROCYTIC HYPERTROPHY IN RAT CEREBRAL-CORTEX FROM EARLY TO LATE ADULTHOOD
SYNAPTIC REMODELING AND ASTROCYTIC HYPERTROPHY IN RAT CEREBRAL-CORTEX FROM EARLY TO LATE ADULTHOOD
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DOI：
10.1016/0197-4580(82)90038-0
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发表时间：
1982-01-01
影响因子：
4.2
通讯作者：
JONES, DG
中科院分区：
文献类型：
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作者：
ADAMS, I;JONES, DG
3、6、10、17月龄大鼠顶叶皮质分子层超微结构观察发现除了典型的突触外，还有各种非典型的突触轮廓。非典型突触常位于肥大的星形胶质细胞轮廓附近，有时完全被星形胶质细胞突起包围。突触前末梢不含小泡或含有少量变形的小泡。偶见空突触后终末。3-10个月时，星形胶质细胞的总表面积和非典型突触的数量显著增加。在此期间，反复观察到退化终端的星形胶质细胞收购。由于在这个年龄段，总突触数量没有减少，星形胶质细胞现象可能代表正常大脑中突触丢失和替代的连续循环中的一个阶段。到17个月时，当总突触数量减少时，突触替换可能不是最佳的。
Ultrastructural observation of the molecular layer of the parietal cortex of rats, aged 3, 6, 10 and 17 mo., revealed various atypical synaptic profiles besides typical synapses. The atypical synapses were frequently in the vicinity of hypertrophied astrocytic profiles, and were sometimes completely surrounded by astrocytic processes. The presynaptic terminal contained either no vesicles or a few small distorted vesicles. Vacant postsynaptic terminals were occasionally seen. The total surface area of astrocytic profiles and the numbers of atypical synapses increased significantly between 3-10 mo. The astrocytic acquisition of degenerating terminals was repeatedly observed over this period. Since there was no decrease in total synaptic number at this age, the astrocytic phenomenon may represent a stage in a continuous cycle of synaptic loss and replacement in the normal brain. By 17 mo., when total synapse numbers decrease, synaptic replacement may be less than optimal.