The peptide hormone xenin induces gallbladder contractions in conscious dogs
The peptide hormone xenin induces gallbladder contractions in conscious dogs
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DOI：
10.1111/j.1365-2982.2006.00881.x
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发表时间：
2007-03-01
影响因子：
3.5
通讯作者：
Kuwano, H.
中科院分区：
文献类型：
--
作者：
Kamiyama, Y.;Aihara, R.;Kuwano, H.
Xenin是从人胃粘膜中分离的25个氨基酸的肽。它的生物学活性包括调节肠运动、影响胰腺外分泌和胃酸分泌。然而，氙对胃肠道的生理作用是不完全的。本研究的目的是探讨氙对清醒犬胃肠道运动的影响。通过长期植入的力传感器监测胃肠道和胆囊收缩。在消化间期，静脉注射合成的氙，有或没有预处理胆碱能阻滞剂。此外，还研究了胆囊切除术和迷走神经干切断术后氙的作用。氙诱导胆囊和空肠收缩，虽然剂量依赖性反应只与胆囊收缩。这些作用被抑制预处理胆碱能阻断剂，但没有增强迷走神经干切断术。胆囊切除术完全抑制了空肠收缩。在胃肠道运动方面，氙的唯一直接作用是诱导清醒狗的胆囊收缩。介导xenin作用的神经通路是胆碱能的，但不是迷走神经。这一新的发现表明了氙的新作用。
Xenin is a 25-amino acid peptide isolated from human gastric mucosa. The biological activities of xenin include modulating intestinal motility and affecting exocrine pancreatic secretion and gastric acid secretion. The physiological effect of xenin on the gastrointestinal tract, however, is incomplete. The objective of this study is to investigate the effects of xenin on the gastrointestinal tract motility of conscious dogs. Gastrointestinal tract and gallbladder contractions were monitored by chronically implanted force transducers. Synthetic xenin was injected intravenously during the interdigestive state with or without pretreatment with cholinergic blockers. The effects of xenin following cholecystectomy and truncal vagotomy were also investigated. Xenin induced gallbladder and jejunal contractions, although a dose-dependent response was shown only with gallbladder contractions. These effects were inhibited by pretreatment with cholinergic blockers, but were not enhanced by truncal vagotomy. The jejunal contractions were completely inhibited by cholecystectomy. The only direct effect of xenin in terms of gastrointestinal motility was to induce gallbladder contractions in conscious dogs. The neural pathway mediating xenin's action was cholinergic, but not the vagal. This novel finding indicates a new role of xenin.