Thermogenic capacity and brown fat in rats exercise-trained by running.
Thermogenic capacity and brown fat in rats exercise-trained by running.
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DOI：
10.1016/0026-0495(87)90067-9
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发表时间：
1987
期刊：
影响因子：
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通讯作者：
S. Wickler;J. Stern;Z. Glick;B. Horwitz
中科院分区：
文献类型：
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作者：
S. Wickler;J. Stern;Z. Glick;B. Horwitz
棕色脂肪组织是哺乳动物非颤抖性产热（NST）的主要效应器，由交感神经递质去甲肾上腺素激活。无论是冷暴露还是外源性应用儿茶酚胺引起的去甲肾上腺素水平的长期增加，都会导致NST增加和棕色脂肪产热能力增加。运动训练也伴随着增强的交感神经活动。这种增强可能会改变棕色脂肪的功能。本研究旨在评估跑步运动方案对整个动物NST和棕色脂肪的体内反应的影响。通过在跑步机上跑步（平均17 m/min，0°倾斜，持续90 min/d）训练大鼠至少6周。通过监测对去甲肾上腺素输注反应的耗氧量来评估整个动物的NST能力。作为棕色脂肪对全身NST的贡献的量度，测量了组织的质量和去甲肾上腺素刺激的血流（微球技术）。这些变量在运动组（n = 10）和久坐组（n = 10）之间没有差异。也就是说，两组之间在静息耗氧量、去甲肾上腺素诱导的耗氧量、棕色脂肪质量和棕色脂肪血流量方面没有显著差异-无论是以每克组织表示还是以总组织血流量表示（即，组织质量×每克血流量）。需要进一步的研究来解释棕色脂肪对运动时交感神经活动增加和冷暴露时交感神经活动增加的不同反应。
Brown adipose tissue, a major effector of nonshivering thermogenesis (NST) in mammals, is activated by the sympathetic neurotransmitter norepinephrine. Prolonged increases in norepinephrine levels, whether elicited by cold exposure or exogenous application of catecholamines, lead to increased NST and increased thermogenic capacity of brown fat. Exercise training is also accompanied by enhanced sympathetic activity. The possibility exists that this enhancement may alter brown fat function. The present study was designed to assess the effect of a running exercise regimen on whole animal NST and the in vivo response of brown fat. Rats were trained by running on a treadmill (an average of 17 m/min, 0° incline, for 90 min/d) for a period of at least 6 weeks. Whole animal NST capacity was assessed by monitoring oxygen consumption in response to infusion of norepinephrine. As a measure of the contribution of brown fat to whole body NST, the mass and norepinephrine-stimulated blood flow (microsphere technique) to the tissue were measured. None of these variables differed between the exercised (n = 10) and sedentary (n = 10) groups. That is, there were no significant differences between the two groups with respect to resting oxygen consumption, norepinephrine-induced oxygen consumption, brown fat mass, and brown fat blood flow—whether expressed per gram of tissue or as total tissue blood flow (ie, tissue mass × blood flow per gram). Further study is needed to explain the differential responses of brown fat to the increased sympathetic activity occurring during exercisevthat occurring during cold exposure.