Consensus on the key characteristics of endocrine-disrupting chemicals as a basis for hazard identification
Consensus on the key characteristics of endocrine-disrupting chemicals as a basis for hazard identification
复制标题
DOI：
10.1038/s41574-019-0273-8
复制
发表时间：
2020-01-01
影响因子：
40.5
通讯作者：
Zoeller, R. Thomas
中科院分区：
文献类型：
--
作者：
La Merrill, Michele A.;Vandenberg, Laura N.;Zoeller, R. Thomas
内分泌干扰化学品（EDCs）是干扰激素作用的外源性化学品，从而增加了不良健康后果的风险，包括癌症，生殖障碍，认知缺陷和肥胖。复杂的机制研究文献提供了EDC暴露危害的证据，但没有广泛接受的系统方法来整合这些数据，以帮助识别EDC危害。受使用关键特征（KC）改进致癌物危害识别工作的启发，我们基于对激素作用和EDC效应的了解，开发了10种EDC KC。在本专家共识声明中，我们描述了识别这些KC的逻辑以及可用于评估其中几种KC的检测方法。我们反思如何这十个KC可以用来识别，组织和利用机械数据时，评价化学品作为内分泌干扰物，我们使用己烯雌酚，双酚A和高氯酸盐作为例子来说明这种方法。
Endocrine-disrupting chemicals (EDCs) are exogenous chemicals that interfere with hormone action, thereby increasing the risk of adverse health outcomes, including cancer, reproductive impairment, cognitive deficits and obesity. A complex literature of mechanistic studies provides evidence on the hazards of EDC exposure, yet there is no widely accepted systematic method to integrate these data to help identify EDC hazards. Inspired by work to improve hazard identification of carcinogens using key characteristics (KCs), we have developed ten KCs of EDCs based on our knowledge of hormone actions and EDC effects. In this Expert Consensus Statement, we describe the logic by which these KCs are identified and the assays that could be used to assess several of these KCs. We reflect on how these ten KCs can be used to identify, organize and utilize mechanistic data when evaluating chemicals as EDCs, and we use diethylstilbestrol, bisphenol A and perchlorate as examples to illustrate this approach.