Probabilistic approach to a proliferation and migration dichotomy in tumor cell invasion
Probabilistic approach to a proliferation and migration dichotomy in tumor cell invasion
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DOI：
10.1103/physreve.77.031911
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发表时间：
2008-03-01
影响因子：
2.4
通讯作者：
Iomin, Alexander
中科院分区：
文献类型：
--
作者：
Fedotov, Sergei;Iomin, Alexander
The proliferation and migration dichotomy of the tumor cell invasion is examined within a two-component continuous time random walk (CTRW) model. The balance equations for the cancer cells of two phenotypes with random switching between cell proliferation and migration are derived. The transport of tumor cells is formulated in terms of the CTRW with an arbitrary waiting time distribution law, while proliferation is modeled by a logistic growth. The overall rate of tumor cell invasion for normal diffusion and subdiffusion is determined.
