Survival among Never-Smokers with Lung Cancer in the Cancer Care Outcomes Research and Surveillance Study
Survival among Never-Smokers with Lung Cancer in the Cancer Care Outcomes Research and Surveillance Study
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DOI：
10.1513/annalsats.201504-241oc
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发表时间：
2016-01-01
影响因子：
8.3
通讯作者：
Gould, Michael K.
中科院分区：
文献类型：
--
作者：
Clement-Duchene, Christelle;Stock, Shannon;Gould, Michael K.
基本原理：在目前的、以前的和从不吸烟的肺癌患者中观察到患者特征和结果的差异，但是大多数先前的研究包括很少的从不吸烟者，并且不是前瞻性的。目的：我们使用来自美国一项关于肺癌护理和结果的大型前瞻性研究的数据，比较从不吸烟者和吸烟者的肺癌特征，并检查从不吸烟者的生存率。方法：诊断时的吸烟状况通过自我报告确定，生存率通过医疗记录和癌症登记确定，随访至2010年6月或以后。考克斯回归用于研究吸烟与生存之间的关系，并确定从不吸烟者生存的预测因素。测量和主要结果：在2003年9月1日至2005年10月14日期间诊断为肺癌的3,410名患者中，完成了基线患者调查，有274名从不吸烟者（8%），1,612名曾吸烟者（47%），1，496名当前吸烟者或最近戒烟的吸烟者（44%），28名吸烟状况信息缺失（
Rationale: Differences in patient characteristics and outcomes have been observed among current, former, and never-smokers with lung cancer, but most prior studies included few never-smokers and were not prospective.Objectives: We used data from a large, prospective study of lung cancer care and outcomes in the United States to compare characteristics of never-smokers and smokers with lung cancer and to examine survival among the never-smokers.Methods: Smoking status at diagnosis was determined by self-report and survival was determined from medical records and cancer registries, with follow-up through June 2010 or later. Cox regression was used to examine the association between smoking and survival, and to identify predictors of survival among never-smokers.Measurements and Main Results: Among 3,410 patients with lung cancer diagnosed between September 1, 2003 and October 14, 2005 who completed a baseline patient survey, there were 274 never-smokers (8%), 1,612 former smokers (47%), 1,496 current smokers or smokers who quit recently (44%), and 28 with missing information about smoking status (