Two new daphnane diterpenes from the roots of Stelleropsis tianschanica
Two new daphnane diterpenes from the roots of Stelleropsis tianschanica
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DOI：
10.1080/10286020.2017.1373644
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发表时间：
2018-12-02
影响因子：
1.7
通讯作者：
Zhang, Jing
中科院分区：
文献类型：
--
作者：
Zhao, Dan;Shi, Lei-Ling;Zhang, Jing
从天山驼舌草（Stelleropsis tianschanica）的根部分离得到两种新的瑞香烷型二萜，分别命名为天山萜A和天山萜B。通过化学和光谱分析，包括一维、二维核磁共振分析以及高分辨率电喷雾质谱，确定了它们的结构。对化合物1和2针对HeLa和HCT - 8细胞系的细胞毒活性进行了评估。结果表明，所有化合物对HeLa细胞均显示出较弱的细胞毒性，对HCT - 8细胞无活性。[图表]
Two new daphnane diterpenes named tianchaterpenes A and B were isolated from the roots of Stelleropsis tianschanica. Their structures were elucidated on the basis of chemical and spectral analysis, including 1D, 2D NMR analyses and HRESIMS. Compounds 1 and 2 were evaluated for their cytotoxic activities against HeLa and HCT-8 cell lines. The results showed that all compounds displayed weak cytotoxicities to the HeLa cells and were inactive to the HCT-8 cells.[GRAPHICS].