Use of radiopharmaceuticals in diagnostic nuclear medicine in the United States: 1960-2010.
Use of radiopharmaceuticals in diagnostic nuclear medicine in the United States: 1960-2010.
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DOI：
10.1097/hp.0000000000000261
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发表时间：
2015-05
期刊：
影响因子：
2.2
通讯作者：
Simon SL
中科院分区：
文献类型：
--
作者：
Drozdovitch V;Brill AB;Callahan RJ;Clanton JA;DePietro A;Goldsmith SJ;Greenspan BS;Gross MD;Hays MT;Moore SC;Ponto JA;Shreeve WW;Melo DR;Linet MS;Simon SL
为了重建可靠的核医学相关职业辐射剂量或过去 50 年来患者接受的放射性药物剂量，我们评估了不同时间段使用的放射性药物、其相对使用频率以及所施用活性的典型值。本文介绍了放射性药物临床使用模式变化的数据，并记录了 1960 年至 2010 年间在美国接受诊断性核医学手术的成年患者的活动范围。提供了 15 种诊断成像程序的数据，包括甲状腺扫描和甲状腺摄取、脑部扫描、脑血流、肺灌注和通气、骨、肝脏、肝胆、骨髓、胰腺和肾脏扫描、心脏成像程序、肿瘤定位研究、胃肠道出血定位以及血容量和铁代谢的非影像学研究。通过关键知情人访谈和对这些诊断核医学研究的典型管理活动的综合文献综述，收集了放射性药物相对使用的数据。主要知情人对放射性药物相对使用的反应与已发表的文献一致。这项研究的结果将用于回顾性重建美国放射技术人员队列成员的诊断放射性药物的职业和个人医疗辐射剂量，以及重建其他美国工作人员或患者群体的职业或患者辐射暴露的辐射剂量。
To reconstruct reliable nuclear medicine-related occupational radiation doses or doses received as patients from radiopharmaceuticals over the last five decades, we assessed which radiopharmaceuticals were used in different time periods, their relative frequency of use, and typical values of the administered activity. This paper presents data on the changing patterns of clinical use of radiopharmaceuticals and documents the range of activity administered to adult patients undergoing diagnostic nuclear medicine procedures in the U.S. between 1960 and 2010. Data are presented for 15 diagnostic imaging procedures that include thyroid scan and thyroid uptake, brain scan, brain blood flow, lung perfusion and ventilation, bone, liver, hepatobiliary, bone marrow, pancreas, and kidney scans, cardiac imaging procedures, tumor localization studies, localization of gastrointestinal bleeding, and non-imaging studies of blood volume and iron metabolism. Data on the relative use of radiopharmaceuticals were collected using key informant interviews and comprehensive literature reviews of typical administered activities of these diagnostic nuclear medicine studies. Responses of key informants on relative use of radiopharmaceuticals are in agreement with published literature. Results of this study will be used for retrospective reconstruction of occupational and personal medical radiation doses from diagnostic radiopharmaceuticals to members of the U.S. radiologic technologist’s cohort and in reconstructing radiation doses from occupational or patient radiation exposures to other U.S. workers or patient populations.