Wide range of perioperative drugs and doses used in inguinal hernia repairs for premature infants.

Wide range of perioperative drugs and doses used in inguinal hernia repairs for premature infants.
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早产儿腹股沟疝修补术中使用的围手术期药物和剂量范围广泛。

DOI:
10.1038/s41372-020-00864-z
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发表时间:
2021-03
期刊:
Journal of perinatology : official journal of the California Perinatal Association
影响因子:
--
通讯作者:
Jackson WM
Jackson WM
中科院分区:
其他
文献类型:
--
作者:
Dorismond C;Hunter SE;McNaull PP;Zimmerman KO;Benjamin DK;Greenberg RG;Corey KM;Laughon MM;Jackson WM

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描述早产儿腹股沟疝(IH)修补术围手术期常用药物的类型和剂量。单中心、回顾性队列研究2010-2015年间,共有112名早产儿接受了IH修复术。在IH修复过程中使用了21种药物,每个婴儿平均接受7种药物。对乙酰氨基酚(88%)、布比卡因(84%)、顺铂(74%)、七氟烷(72%)和丙泊酚(71%)是最常用的药物。32名婴儿接受了IH修复的额外手术。额外的手术与围手术期药物的数量增加无关,然而,额外手术的婴儿暴露于更高的累积剂量的顺式利库铵(p<0.001)和芬太尼(p=0.002)。在该人群中,即使在一个中心内,用于普通外科手术的药物和剂量也存在很大差异。未来的研究应关注本研究中描述的最常用围手术期药物的安全性和有效性。
Characterize the types and doses of commonly administered perioperative drugs in inguinal hernia (IH) repair for premature infants. Single-center, retrospective cohort study In total, 112 premature infants underwent IH repair between 2010–2015. Twenty-one drugs were used during IH repair, with each infant receiving a median 7 drugs. Acetaminophen (88%), bupivacaine (84%), cisatracurium (74%), sevoflurane (72%), and propofol (71%) were the most commonly used agents. Thirty-two infants underwent additional procedures with IH repair. Additional procedures were not associated with a higher number of perioperative drugs, however infants with additional procedures were exposed to higher cumulative doses of cisatracurium (p<0.001) and fentanyl (p=0.002). There is wide variability in the drugs and doses used for a common surgical procedure in this population, even within a single center. Future research should focus on the safety and efficacy of the most commonly used perioperative drugs described in this study.
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