Brain natriuretic peptide is a prognostic parameter in chronic lung disease
Brain natriuretic peptide is a prognostic parameter in chronic lung disease
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DOI：
10.1164/rccm.200510-1545oc
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发表时间：
2006-04-01
影响因子：
24.7
通讯作者：
Behr, J
中科院分区：
文献类型：
--
作者：
Leuchte, HH;Baumgartner, RA;Behr, J
原理：检测慢性肺病患者的肺动脉高压具有预后意义。脑钠肽（BNP）已被建议作为一个非侵入性的标记物的存在和严重程度的肺动脉高压的objectives.Objectives：我们评估循环BNP水平作为一个参数的存在和严重程度的肺动脉高压的慢性肺疾病patients.Methods：BNP水平测定在176例连续的各种肺部疾病。进行右心导管插入术、肺功能检查和6分钟步行试验。平均随访时间为近1 yr.测量和主要结果：显着的肺动脉高压（平均肺动脉压> 35毫米汞柱）被诊断为超过四分之一的患者，并导致运动耐量下降和预期寿命。BNP浓度升高可识别显著的肺动脉高压，敏感性为0.85，特异性为0.88，并可预测死亡率。此外，BNP作为一个独立的肺功能损害或低氧血症的死亡的危险因素，在单因素和多因素analysis.Conclusion：我们建议BNP作为一个预后指标，并作为筛选参数显着肺动脉高压在慢性肺疾病。
Rationale:The detection of pulmonary hypertension in patients with chronic lung disease has prognostic implications. The brain natriuretic peptide (BNP) has been suggested as a noninvasive marker for the presence and severity of pulmonary hypertension.Objectives: We evaluated circulating BNP levels as a parameter for the presence and severity of pulmonary hypertension in patients with chronic lung disease.Methods: BNP levels were measured in 176 consecutive patients with various pulmonary diseases. Right heart catheterization, lung functional testing, and a 6-min walk test were performed. The mean follow-up time was nearly 1 yr.Measurements and Main Results: Significant pulmonary hypertension (mean pulmonary artery pressure > 35 mm Hg) was diagnosed in more than one-fourth of patients and led to decreased exercise tolerance and life expectancy. Elevated BNP concentrations identified significant pulmonary hypertension with a sensitivity of 0.85 and specificity of 0.88 and predicted mortality. Moreover, BNP served as a risk factor of death independent of lung functional impairment or hypoxemia in uni- and multivariate analysis.Conclusion:We suggest BNP as a prognostic marker and as screening parameter for significant pulmonary hypertension in chronic lung disease.