Chlorogenic Acid Improves PTSD-like Symptoms and Associated Mechanisms.
Chlorogenic Acid Improves PTSD-like Symptoms and Associated Mechanisms.
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DOI：
10.2174/1570159x19666210111155110
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发表时间：
2021
影响因子：
5.3
通讯作者：
Wang, Yong-Tang
中科院分区：
文献类型：
--
作者：
Chen, Xing-Dong;Tang, Jun-Jie;Feng, Shuang;Huang, Hua;Lu, Feng-Nian;Lu, Xiu-Min;Wang, Yong-Tang
关键词：
Chlorogenic acid (CGA) is a kind of traditional Chinese medicine, abundant in honeysuckle and eucommia, and has a wide range of biological activities, and pharmacological effects. Previous studies have shown that CGA can regulate learning, memory, cognitive ability, coupled with improvement to anxiety, depression, and other post-traumatic stress disorder (PTSD)-like symptoms. This article explores the protective effects of CGA on neurons through its anti-apoptotic effect, inhibition of neuroinflammation and oxidative stress, which may be the mechanisms of its improvement of PTSD-like symptoms. It may provide a new therapeutic strategy for the treatment of PTSD and its comorbidities.
