Tumor radiosensitivity (SF2) is a prognostic factor for local control in head and neck cancers
Tumor radiosensitivity (SF2) is a prognostic factor for local control in head and neck cancers
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DOI：
10.1016/s0360-3016(99)00373-9
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发表时间：
2000-01-01
影响因子：
7
通讯作者：
Mercke, C
中科院分区：
文献类型：
--
作者：
Björk-Eriksson, T;West, C;Mercke, C
目的：前瞻性地评估SF 2的预后价值的局部控制和生存的患者接受放射治疗的头颈cancer.Methods和材料：知情同意后的肿瘤标本，从156例原发性癌的头部和颈部region. The。使用软琼脂克隆形成试验评估样本的体外生长能力（集落形成效率，CFE）和固有放射敏感性，测量为2戈伊（SF 2）下的存活分数。患者主要接受新辅助化疗加放疗，通常是加速外照射和间质放疗的组合。结果：156例标本中110例生长成功，99例获得SF 2值，84例接受根治性治疗。平均随访25个月，84例肿瘤的SF 2中位数为0.40（范围7-65）14例局部复发患者的肿瘤SF 2中位数为0.53，显著高于70例无局部复发患者的肿瘤SF 2中位数0.38（p = 0.015），肿瘤SF 2是局部控制的重要预后因素（p = 0.036）但不适用于总生存期（p = 0.20），在双变量和考克斯多变量分析中，肿瘤SF 2是局部控制的独立预后因素。这项研究表明，肿瘤放射敏感性测量为SF 2是一个重要的预后因素，局部控制头颈癌，（C）2000年爱思唯尔科学公司。
Purpose: To evaluate prospectively the prognostic value of SF2 for local control and survival in patients undergoing radiation therapy for head and neck cancers.Methods and materials: Following informed consent tumor specimens were obtained from 156 patients with primary carcinomas of the head and neck region. The specimens were assessed for the ability to grow in vitro (colony forming efficiency, CFE) and inherent radiosensitivity measured as the surviving fraction at 2 Gy (SF2) using a soft-agar clonogenic assay. Patients were treated mainly with neoadjuvant chemotherapy plus radiation therapy usually as a combination of accelerated external beam and interstitial radiotherapy. The probabilities of local control and survival were analyzed by univariate, bivariate and Cox multivariate analyses,Results: Successful growth was achieved in 110/156 specimens and SF2 values were obtained from 99/156, Eighty four out of these patients underwent radical treatment. The median SF2 value for the 84 tumors was 0.40, At a mean follow-up time of 25 months (range 7-65) the median SF2 value of tumors from 14 patients who developed local recurrence was 0.53, which was significantly higher than the median of 0.38 for tumors from 70 patients without local recurrence (p = 0.015), Tumor SF2 was a significant prognostic factor for local control (p = 0.036) but not for overall survival (p = 0.20), Tumor SF2 was an independent prognostic factor for local control within bivariate and Cox multivariate analyses.Conclusions: This study has shown that tumor radiosensitivity measured as SF2 is a significant prognostic factor for local control in head and neck cancers, (C) 2000 Elsevier Science Inc.