The process of a Y-loss event in an XO/XO mammal, the Ryukyu spiny rat
The process of a Y-loss event in an XO/XO mammal, the Ryukyu spiny rat
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DOI：
10.1007/s00412-010-0275-8
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发表时间：
2010-10-01
期刊：
影响因子：
1.6
通讯作者：
Matsuda, Yoichi
中科院分区：
文献类型：
--
作者：
Kuroiwa, Asato;Ishiguchi, Yasuko;Matsuda, Yoichi
琉球大鼠Tokudaia osimensis具有XO/XO性染色体结构，缺乏Y染色体和哺乳动物性别决定基因SRY。为了研究y丢失事件，我们追踪了基因组中的三个原y相关基因，RBMY1A1， EIF2S3Y和KDM5D。原来的y连锁RBMY1A1和SRY一起丢失，剩余的RBMY1A1是常染色体上加工过的假基因。相比之下，由于EIF2S3Y和KDM5D从Y染色体易位到X染色体和/或常染色体，它们在两性基因组中都是保守的。此外，这些基因在两性性腺和大脑中都有表达。我们的研究表明，具有重要男性功能的Y连锁基因的缺失是Y染色体消失的必要条件。这些功能可能是通过获得新基因而保留下来的，因此，y的丧失对这个物种的维持没有有害的影响。
The Ryukyu spiny rat, Tokudaia osimensis, has an XO/XO sex chromosome constitution, lacking a Y chromosome and the mammalian sex-determining gene SRY. To investigate the Y-loss event, we traced three proto-Y-linked genes, RBMY1A1, EIF2S3Y, and KDM5D, in the genome. The original Y-linked RBMY1A1 was lost as well as SRY, and the remaining RBMY1A1 was a processed pseudogene on autosome. In contrast, EIF2S3Y and KDM5D were conserved in genomes of both sexes as a result of their translocation from the Y chromosome to the X chromosome and/or autosomes. Furthermore, these genes were expressed in gonads and brains of both sexes. Our study indicated a loss of Y-linked genes with important male functions to be necessary for the Y chromosome to disappear. These functions might have been retained through the acquisition of new genes, and therefore, the Y-loss has had no harmful effect on the maintenance of this species.