Activation of midbrain structures by associative novelty and the formation of explicit memory in humans.
Activation of midbrain structures by associative novelty and the formation of explicit memory in humans.
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DOI：
10.1101/lm.75004
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发表时间：
2004-07
影响因子：
2
通讯作者：
B. Schott;Daniela Sellner;CorinnaJ . Lauer;R. Habib;J. Frey;S. Guderian;H. Heinze;E. Düzel
中科院分区：
文献类型：
--
作者：
B. Schott;Daniela Sellner;CorinnaJ . Lauer;R. Habib;J. Frey;S. Guderian;H. Heinze;E. Düzel
最近的证据表明，在海马和多巴胺能神经调制起源于腹侧被盖区和中脑内侧黑质的记忆形成之间的密切功能关系。在这里，我们报告了两个功能磁共振成像研究健康年轻人的视觉记忆中脑激活。在第一项研究中，参与者通过学习物品的位置或身份来区分熟悉和新颖的成对物品配置。在第二项研究中，参与者通过对单词的愉快程度进行评级或计算音节来学习单词。腹侧被盖区和内侧黑质的激活增加联想新奇（第一项研究）和随后的自由回忆性能（第二项研究）。在这两项研究中，这种激活伴随着海马激活，但不受研究任务的影响。因此，中脑区域似乎选择性地参与了依赖于大脑皮层的联想新奇性和外显记忆形成过程，但似乎不受其他任务相关方面的影响。
Recent evidence suggests a close functional relationship between memory formation in the hippocampus and dopaminergic neuromodulation originating in the ventral tegmental area and medial substantia nigra of the midbrain. Here we report midbrain activation in two functional MRI studies of visual memory in healthy young adults. In the first study, participants distinguished between familiar and novel configurations of pairs of items which had been studied together by either learning the location or the identity of the items. In the second study, participants studied words by either rating the words' pleasantness or counting syllables. The ventral tegmental area and medial substantia nigra showed increased activation by associative novelty (first study) and subsequent free recall performance (second study). In both studies, this activation accompanied hippocampal activation, but was unaffected by the study task. Thus midbrain regions seem to participate selectively in hippocampus-dependent processes of associative novelty and explicit memory formation, but appear to be unaffected by other task-relevant aspects.