Increased plasma interleukin-1 receptor antagonist levels in men with visceral obesity
Increased plasma interleukin-1 receptor antagonist levels in men with visceral obesity
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DOI：
10.1080/07853890903022801
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发表时间：
2009-01-01
影响因子：
4.4
通讯作者：
Despres, Jean-Pierre
中科院分区：
文献类型：
--
作者：
Cartier, Amelie;Bergeron, Jean;Despres, Jean-Pierre
背景。脂肪组织（AT）是白介素1受体拮抗剂（IL-1Ra）的重要来源。其表达在肥胖者中显着增加。目的和方法。量化 IL-1Ra 与身体脂肪分布的关联，并检查 IL-1Ra 和内脏肥胖对某些心脏代谢风险 (CMR) 标志物变化的各自贡献。测量了 117 名健康非糖尿病男性样本（年龄：44.9 +/- 10.1 岁；体重指数 (BMI)：28.8 +/- 4.5 kg/m(2)）的血浆 IL-1Ra 水平。结果。血浆 IL-1Ra 水平与 BMI、腰围、内脏和皮下 AT 呈正相关（0.39
Background. Adipose tissue (AT) is an important source of interleukin-1 receptor antagonist (IL-1Ra). Its expression is markedly increased in obesity.Aims and methods. To quantify the associations of IL-1Ra with body fat distribution as well as to examine the respective contributions of IL-1Ra and visceral adiposity to the variation in some cardiometabolic risk (CMR) markers. Plasma IL-1Ra levels were measured in a sample of 117 healthy non-diabetic men (age: 44.9 +/- 10.1 years; body mass index (BMI): 28.8 +/- 4.5 kg/m(2)).Results. Plasma IL-1Ra levels correlated positively with BMI, waist girth, and visceral and subcutaneous AT (0.39