Inter-Individual Variation during Transcranial Direct Current Stimulation and Normalization of Dose Using MRI-Derived Computational Models.
Inter-Individual Variation during Transcranial Direct Current Stimulation and Normalization of Dose Using MRI-Derived Computational Models.
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DOI：
10.3389/fpsyt.2012.00091
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发表时间：
2012
影响因子：
4.7
通讯作者：
Bikson M
中科院分区：
文献类型：
--
作者：
Datta A;Truong D;Minhas P;Parra LC;Bikson M
背景资料：经颅直流电刺激（tDCS）是一种非侵入性、多功能和安全的神经调节技术，正在研究用于治疗神经精神疾病，辅助康复和增强健康成人的认知能力。尽管结果令人鼓舞，但反应性存在差异。变异性的一个潜在来源是输送到大脑的电流强度，这是操作员控制的tDCS剂量（电极导联和总施加电流）和受试者特定解剖结构的函数。我们感兴趣的是这种变异性在解剖学上典型的成年人和方法，以规范个体间的差异，通过定制tDCS剂量的规模。计算FEM模拟是预测tDCS期间脑电流的标准技术，并且可以基于受试者特定的解剖MRI。目的：为了研究这种变异性，我们对三名成人（年龄34-41岁，一名女性）的多个tDCS导联进行了建模。结果：传统的垫刺激导致所有受试者的垫之间的最大电流的扩散调制。一名受试者的衬垫正下方有高电流，而峰值诱导皮质电流的位置可变。高清tDCS导联组合导致所有受试者的电流限制在环周长内。所有受试者和导联的电流分布受皮质脑回/脑沟细节的影响。结论：该数据表明受试者特异性建模可促进一致且更有效的tDCS。
Background: Transcranial Direct Current Stimulation (tDCS) is a non-invasive, versatile, and safe neuromodulation technology under investigation for the treatment of neuropsychiatric disorders, adjunct to rehabilitation, and cognitive enhancement in healthy adults. Despite promising results, there is variability in responsiveness. One potential source of variability is the intensity of current delivered to the brain which is a function of both the operator controlled tDCS dose (electrode montage and total applied current) and subject specific anatomy. We are interested in both the scale of this variability across anatomical typical adults and methods to normalize inter-individual variation by customizing tDCS dose. Computational FEM simulations are a standard technique to predict brain current flow during tDCS and can be based on subject specific anatomical MRI. Objective: To investigate this variability, we modeled multiple tDCS montages across three adults (ages 34–41, one female). Results: Conventional pad stimulation led to diffuse modulation with maximum current flow between the pads across all subjects. There was high current flow directly under the pad for one subject while the location of peak induced cortical current flow was variable. The High-Definition tDCS montage led to current flow restricted to within the ring perimeter across all subjects. The current flow profile across all subjects and montages was influenced by details in cortical gyri/sulci. Conclusion: This data suggests that subject specific modeling can facilitate consistent and more efficacious tDCS.