Does Long-Term Treatment of Schizophrenia With Antipsychotic Medications Facilitate Recovery?
Does Long-Term Treatment of Schizophrenia With Antipsychotic Medications Facilitate Recovery?
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DOI：
10.1093/schbul/sbt034
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发表时间：
2013-09-01
影响因子：
6.6
通讯作者：
Jobe, Thomas H.
中科院分区：
文献类型：
--
作者：
Harrow, Martin;Jobe, Thomas H.
抗精神病药物被视为精神分裂症短期和长期治疗的基石。然而，关于抗精神病药物长期(10年或更长时间)疗效的证据喜忧参半。双盲停止研究表明，未用药的精神分裂症患者在最初的6-10个月内复发明显更多，但也呈现出一些潜在的自相矛盾的特征。对这些问题进行了讨论。
Antipsychotic medications are viewed as cornerstones for both the short-term and long-term treatment of schizophrenia. However, evidence on long-term (10 or more years) efficacy of antipsychotics is mixed. Double-blind discontinuation studies indicate significantly more relapses in unmedicated schizophrenia patients in the first 6-10 months, but also present some potentially paradoxical features. These issues are discussed.