HYPERLIPIDEMIA OF PREGNANCY IN NORMAL AND COMPLICATED PREGNANCIES
HYPERLIPIDEMIA OF PREGNANCY IN NORMAL AND COMPLICATED PREGNANCIES
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DOI：
10.1016/0002-9378(79)90469-1
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发表时间：
1979-01-01
影响因子：
9.8
通讯作者：
NESTEL, PJ
中科院分区：
文献类型：
--
作者：
POTTER, JM;NESTEL, PJ
用超速离心法和沉淀法分离的脂蛋白胆固醇和甘油三酯的浓度在整个妊娠和产褥期有规律地变化，共43例。血浆胆固醇浓度平均升高约50%，主要升高发生在妊娠中期。血浆甘油三酯浓度升高3倍，在妊娠晚期达到峰值。所有主要的脂蛋白都参与了这些变化。在极低密度脂蛋白中，这两种脂类与未怀孕妇女的比例上升，但在低密度和高密度脂蛋白中，甘油三酯与胆固醇的比率上升。低密度脂蛋白中甘油三酯的丰富反映了中等密度脂蛋白(密度为1.006至1.019)的包含。高血压或先兆子痫的发生导致极低密度脂蛋白中的脂类进一步增加。高胆固醇血症在有高胆固醇血症的妇女中最严重，第三次怀孕的妇女的血浆胆固醇浓度高于第一次怀孕的妇女。分娩后24小时内，胆固醇和甘油三酯浓度均显著下降，这在所有脂蛋白中都有所反映。产后甘油三酯水平持续下降，迅速恢复到非妊娠水平，而低密度脂蛋白中的胆固醇在产后至少6-7wk内保持较高水平。
Alterations in the concentrations of the cholesterol and triglyceride moieties of lipoproteins separated by ultracentrifugation and precipitation methods were studied at frequent intervals throughout pregnancy and the puerperium in a group of 43 women. The plasma cholesterol concentration rose on the average by about 50%, the major increase occurring in the 2nd trimester. The plasma triglyceride concentration rose 3-fold, reaching its peak during the 3rd trimester. All major lipoproteins participated in these changes. In very-low-density lipoproteins, both lipids rose in proportion to the ratio in nonpregnant women, but in low-density and high-density lipoproteins, the ratio of triglyceride to cholesterol rose. The triglyceride enrichment in low-density lipoproteins reflected the inclusion of intermediate-density lipoproteins (density 1.006 to 1.019). The occurrence of hypertension or pre-eclampsia led to a further increase in lipids in very-low-density lipoproteins. Hypercholesterolemia was greatest in women with pre-existing hypercholesterolemia and women in the 3rd pregnancy showed higher plasma cholesterol concentrations than women in the 1st pregnancy. Both cholesterol and triglyceride concentrations decreased significantly within 24 h of delivery and this was reflected in all lipoproteins. While triglyceride levels continued to decrease rapidly returning to nonpregnant levels during the puerperium, cholesterol in low-density lipoprotein remained elevated for at least 6-7 wk post-partum.