Studies on search for bioactive natural products targeting TRAIL signaling leading to tumor cell apoptosis
Studies on search for bioactive natural products targeting TRAIL signaling leading to tumor cell apoptosis
复制标题
DOI：
10.1002/med.20123
复制
发表时间：
2008-09-01
影响因子：
13.3
通讯作者：
Ohtsuki, Takashi
中科院分区：
文献类型：
--
作者：
Ishibashi, Mastimi;Ohtsuki, Takashi
肿瘤坏死因子相关凋亡诱导配体（tumor necrosis factor related apoptosis inducing ligand，TRAIL）能诱导许多转化细胞凋亡，但不能诱导正常细胞凋亡。在我们从各种自然资源如植物和微生物中寻找具有生物活性的天然产物的研究中，我们最近鉴定了几种表现出与TRAIL信号传导相关的活性的天然产物。姜黄二聚体倍半萜类化合物对TRAIL受体基因表达和蛋白水平具有增强活性。从豆科植物中分离得到几个新的天然产物，命名为brandisianins。通过我们的筛选研究发现，崖豆藤具有靶向TRAIL-受体表达增强活性。从菊科植物艾纳香（Blumea balsamifera）中提取的二氢黄酮醇（BB 1）和从黏菌中分离的一种新的邻氨基苯甲酰基脯氨酸-吲哚生物碱fuligocandin B具有逆转-TRAIL抗性的作用。(C)2008 Wiley Periodicals，Inc.
Tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL) induces apoptosis in many transformed cells but not in normal cells and, hence, has been expected as a new anticancer strategy. During our studies on search for bioactive natural products from various natural resources such as plants and microorganisms, we recently indetified several natural products which exhibited activities related to TRAIL signaling. Dimeric sesquiterpenoids isolated from Zingiberaceous plant, Curcuma parviflora, showed enhancement activity of gene expression of TRAIL-receptor and TRAIL-receptor protein level. Several new isoflavone natural products, named brandisianins, were isolated from Leguminosaeous plant. Millettia brandisiana, by our screening study targeting TRAIL-receptor expression enhancement activity. A dihydroflavonol (BB1) that was extracted from Compositaeous plant, Blumea balsamifera, and fuligocandin B, a new anthranilylproline-indole alkaloid isolated from myxomycete were found to exhibit reversal effect of-TRAIL resistance activity. (C) 2008 Wiley Periodicals, Inc.