The level of urinary semaphorin3A is associated with disease activity in patients with minimal change nephrotic syndrome.
The level of urinary semaphorin3A is associated with disease activity in patients with minimal change nephrotic syndrome.
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DOI：
10.2147/ijnrd.s132980
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发表时间：
2017
影响因子：
2
通讯作者：
Makino H
中科院分区：
文献类型：
--
作者：
Inoue-Torii A;Kitamura S;Wada J;Tsuji K;Makino H
Semaphorin3A是一种已知参与器官发生、免疫反应和癌症的分泌蛋白。在肾脏中，semaphorin3A在肾小球足细胞、远端小管和集合小管中表达，被认为在肾脏发育和功能的调节中起作用。我们检测了72例肾脏疾病患者和5名健康志愿者的血清和尿液信号蛋白3a水平。诊断为基底膜薄病（n=4）、微小改变肾病综合征（MCNS; n=22）、IgA肾炎（n=21）、膜性肾病（n=16）和局灶节段性肾小球硬化（n=9）。MCNS患者尿信号蛋白3a水平在各疾病组中均较高。我们还研究了7例MCNS患者从发病到药物治疗缓解期间的尿信号蛋白3a水平。缓解前状态的MCNS患者尿信号蛋白3a水平高于接受免疫抑制治疗的缓解后状态患者。这些结果提示尿信号蛋白3a水平与MCNS活性相关。Semaphorin3A有潜力作为MCNS的生物标志物，阐明治疗的反应性，也可用于检查其他肾小球疾病伴蛋白尿。
Semaphorin3A is a secreted protein known to be involved in organogenesis, immune responses and cancer. In the kidney, semaphorin3A is expressed in the glomerular podocytes, distal tubules and collecting tubules, and believed to play a role in the regulation of the kidney development and function. We examined the serum and urinary semaphorin3A levels in 72 patients with renal disease and 5 healthy volunteers. The patients had been diagnosed with thin basement membrane disease (n=4), minimal change nephrotic syndrome (MCNS; n=22), IgA nephritis (n=21), membranous nephropathy (n=16) and focal segmental glomerular sclerosis (n=9). The level of urinary semaphorin3A in MCNS patients tended to be relatively high among all disease groups. We also investigated the urinary semaphorin3A level in 7 patients with MCNS from disease onset to remission during the drug therapy. MCNS patients in pre-remission states had higher urinary semaphorin3A levels than those in post-remission states receiving immunosuppressive therapies. These results suggested that the urinary semaphorin3A level correlates with the MCNS activity. Semaphorin3A has the potential as a biomarker for MCNS to clarify the reactivity for therapy and may be useful in examining other glomerular diseases with proteinuria as well.