A comparison of in vitro maturation and in vitro fertilization for women with polycystic ovaries
A comparison of in vitro maturation and in vitro fertilization for women with polycystic ovaries
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DOI：
10.1016/s0029-7844(02)02193-2
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发表时间：
2002-10-01
影响因子：
7.2
通讯作者：
Tan, SL
中科院分区：
文献类型：
--
作者：
Child, TJ;Phillips, SJ;Tan, SL
目的：为了建立治疗的相对成功的非刺激性体外成熟（IVM）的卵母细胞或刺激的体外受精（IVF）在多囊卵巢妇女接受辅助受孕treatment.METHODS：病例对照研究包括107 IVM和107 IVF周期匹配的年龄和不孕症的原因。体外成熟患者在非刺激周期、体外卵母细胞成熟和受精期间接受了未成熟卵母细胞的经阴道回收。IVF组在垂体抑制后进行卵巢刺激。两组胚胎移植周期相同。主要观察指标包括成熟卵母细胞数、胚胎数、着床率、妊娠率、活产率和并发症发生率。结果：体外成熟组体外培养后，每次取卵获得成熟卵母细胞7.8个，胚胎6.1个。IVF获得12.0个成熟卵母细胞（P <0.01）和9.3个胚胎（P <0.01）。每次取卵的IVM妊娠率和活产率分别为26.2%和15.9%，而IVF为38.3%和26.2%（无显著性）。体外受精胚胎的种植率（17.1%）高于体外成熟胚胎（9.5%）（P <0.01）。IVF患者中有12例（11.2%）发生中度或重度卵巢过度刺激综合征，而IVM组无一例发生（P <0.01）。结论：我们的研究结果表明，对于需要辅助受孕的多囊卵巢妇女，IVM是传统IVF治疗的一种有前途的替代方案。(C)2002年由美国妇产科医师学会。
OBJECTIVE: To establish the relative success of treatment by unstimulated in vitro maturation (IVM) of oocytes or stimulated in vitro fertilization (IVF) in women with polycystic ovaries undergoing assisted conception treatment.METHODS: The case-control study included 107 IVM and 107 IVF cycles matched for age and cause of infertility. In vitro maturation patients underwent transvaginal recovery of immature oocytes during an unstimulated cycle, in vitro oocyte maturation, and fertilization. Those in die IVF group underwent ovarian stimulation after pituitary suppression. Embryos were transferred in the same cycle in both groups. Main outcome measures included numbers of mature oocytcs and embryos produced, and rates of implantation, pregnancy, live birth, and complications.RESULTS: In the IVM group after in vitro culture, 7.8 mature oocytes and 6.1 embryos were obtained per retrieval. With IVF, 12.0 mature oocytes (P < .01) and 9.3 embryos (P < .01) were obtained. The IVM pregnancy and live birth rates per retrieval were 26.2% and 15.9% compared with 38.3% and 26.2% for IVF (nonsignificant). The implantation rate of IVF-derived embryos was higher (17.1% versus 9.5%) than that for IVM (P < .01). There were 12 cases (11.2%) of moderate or severe ovarian hyperstimulation syndrome in IVF patients, compared with none in the IVM group (P < .01).CONCLUSION: Our results suggest that for women with polycystic ovaries who require assisted conception, IVM is a promising alternative to conventional IVF treatment. (C) 2002 by The American College of Obstetricians and Gynecologists.