Designing redox metalloproteins from bottom-up and top-down perspectives
Designing redox metalloproteins from bottom-up and top-down perspectives
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DOI：
10.1016/s0959-440x(03)00108-8
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发表时间：
2003-08-01
影响因子：
6.8
通讯作者：
Barker, PD
中科院分区：
文献类型：
--
作者：
Barker, PD
氧化还原活性金属蛋白的设计从两个不同的方向进行了探讨。从头设计方法最近已经达到了一个重要的阶段，在这个阶段，已经获得了几种不同设计的金属蛋白的结构信息。这一新信息突显了这种方法的真正挑战。另一种涉及进化蛋白质再工程的方法最近也取得了重大进展。
The design of redox-active metalloproteins has been approached from two different directions. The de novo design approach has recently reached an important stage, at which structural information on several different designed metalloproteins has been obtained. This new information highlights the real challenge of this approach. The alternative approach involving re-engineering of evolved proteins has also made significant advances recently.