Vobatensines A-F, Cytotoxic Iboga-Vobasine Bisindoles from Tabernaemontana corymbosa
Vobatensines A-F, Cytotoxic Iboga-Vobasine Bisindoles from Tabernaemontana corymbosa
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DOI：
10.1021/acs.jnatprod.5b01117
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发表时间：
2016-04-01
影响因子：
5.1
通讯作者：
Kam, Toh-Seok
中科院分区：
文献类型：
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作者：
Sim, Dawn Su-Yin;Teoh, Wuen-Yew;Kam, Toh-Seok
从马来亚Tabernaemontana corymbosa的茎皮提取物中分离得到6个新的双吲哚生物碱，vobatensines a - f（1-6）和4个已知的双吲哚（8-11）。这些生物碱的结构是根据光谱数据分析确定的，对于伏巴辛A (1)， B(2)和16'-脱碳甲氧基伏巴辛胺(8)也通过部分合成得到了证实。其中9种生物碱（1- 5,8 -11）对人KB、PC-3、LNCaP、HCT 116、HT-29、MCF7、MDA-MB-231和A549癌细胞表现出明显的体外生长抑制活性。
Six new bisindole alkaloids of the ibogavobasine type, vobatensines A-F (1-6), in addition to four known bisindoles (8-11), were isolated from a stem bark extract of a Malayan Tabernaemontana corymbosa. The structures of these alkaloids were determined based on analysis of the spectroscopic data and in the case of vobatensines A (1), B (2), and 16'-decarbomethoxyvoacamine (8) also confirmed by partial syntheses. Nine of these alkaloids (1-5, 8-11) showed pronounced in vitro growth inhibitory activity against human KB, PC-3, LNCaP, HCT 116, HT-29, MCF7, MDA-MB-231, and A549 cancer cells.