Growth factors and oncogenes in prostate cancer.
Growth factors and oncogenes in prostate cancer.
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发表时间：
1990-11
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通讯作者：
T. Thompson
中科院分区：
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作者：
T. Thompson
前列腺癌是一个日益严重的医学问题。对前列腺生物学和前列腺癌发展的研究表明，前列腺含有高水平的多肽生长因子，特别是成纤维细胞生长因子（FGF）和转化生长因子（TGF）-β家族的成员。在人前列腺癌组织中已检测到癌基因激活和原癌基因活性升高，包括ras和myc，但对于这种疾病进展中涉及的主要遗传改变尚无共识。体内动物模型表明，相关的生长因子和癌基因可以诱导前列腺组织的癌前病变和恶性病变。需要额外的实验和临床研究来呈现这种重要恶性肿瘤的更清晰的分子特征。
Prostatic cancer is an increasing medical problem. Investigations of the biology of the prostate and the development of prostate cancer have shown that the prostate gland contains high levels of polypeptide growth factors, especially members of the fibroblast growth factor (FGF) and transforming growth factor (TGF)-beta family. Activated oncogenes and elevated proto-oncogene activities including ras and myc have been detected in human prostate cancer tissues, but there is no consensus as to the predominant genetic alterations involved in the progression of this disease. In vivo animal models have shown that relevant growth factors and oncogenes can induce both premalignant and malignant changes in prostate tissue. Additional experimental and clinical studies are needed to present a clearer molecular profile of this important malignancy.