Saccades during visual exploration align hippocampal 3-8 Hz rhythms in human and non-human primates.
Saccades during visual exploration align hippocampal 3-8 Hz rhythms in human and non-human primates.
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DOI：
10.3389/fnsys.2013.00043
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发表时间：
2013
影响因子：
3
通讯作者：
Valiante TA
中科院分区：
文献类型：
--
作者：
Hoffman KL;Dragan MC;Leonard TK;Micheli C;Montefusco-Siegmund R;Valiante TA
灵长类动物的视觉探索依赖于眼跳运动（SEMs），这种运动引起神经抑制和增强的交替。这种调节延伸到视网膜异位区域之外，并被认为有助于感知；然而，扫视也可能影响大脑中对这些探索性事件形成记忆的关键区域。例如，海马体表现出振荡活动，通常与信息编码有关。海马体的振荡是否或如何受到眼球运动的影响尚不清楚。我们记录了人类和猕猴在视觉场景搜索过程中海马的神经活动。在物种中，sem与低频（3-8 Hz）节奏的时间限制排列有关。相位排列不仅取决于眼动本身，还取决于任务，而且频带也不是扫视率的直接结果。海马体频率振荡是由其他哺乳动物在重复的探索行为中产生的，包括拍打、嗅探、回声定位和运动。目前的结果可能反映了在探索过程中支持主动感知的类似而独特的灵长类同源物。
Visual exploration in primates depends on saccadic eye movements (SEMs) that cause alternations of neural suppression and enhancement. This modulation extends beyond retinotopic areas, and is thought to facilitate perception; yet saccades may also influence brain regions critical for forming memories of these exploratory episodes. The hippocampus, for example, shows oscillatory activity that is generally associated with encoding of information. Whether or how hippocampal oscillations are influenced by eye movements is unknown. We recorded the neural activity in the human and macaque hippocampus during visual scene search. Across species, SEMs were associated with a time-limited alignment of a low-frequency (3–8 Hz) rhythm. The phase alignment depended on the task and not only on eye movements per se, and the frequency band was not a direct consequence of saccade rate. Hippocampal theta-frequency oscillations are produced by other mammals during repetitive exploratory behaviors, including whisking, sniffing, echolocation, and locomotion. The present results may reflect a similar yet distinct primate homologue supporting active perception during exploration.