Neurophysiological and subjective profile of marijuana with varying concentrations of cannabinoids
Neurophysiological and subjective profile of marijuana with varying concentrations of cannabinoids
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DOI：
10.1097/00008877-200509000-00023
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发表时间：
2005-09-01
影响因子：
1.6
通讯作者：
de Wit, H
中科院分区：
文献类型：
--
作者：
Ilan, AB;Gevins, A;de Wit, H
本研究探讨了不同大麻素对吸食大麻的主观、行为和神经生理效应的贡献。健康的大麻使用者（2名男性，11名女性）参加了四次会议。他们被随机分配到低或高δ(9)-四氢大麻酚组（THC； 1.8%对3.6%）。在盲法条件下的四个疗程中，受试者吸食含有安慰剂（无活性大麻素）的大麻香烟，或含有低或高水平大麻色胺（CBC； 0.1%对0.5%）和低或高水平大麻二酚（CBD； 0.2%对1.0%）的四氢大麻酚香烟。依赖测量包括主观报告、认知任务表现测量和神经生理测量[脑电图（EEG）和事件相关电位（ERP）]。与安慰剂相比，活性四氢大麻酚香烟对情绪、行为和大脑活动产生了预期的影响。在工作记忆和情景记忆测试中，观察到表现下降，脑电图功率减少和反映注意过程的ERP成分衰减。这些影响大多不依赖于剂量。改变CBC和CBD的浓度并没有改变受试者对任何结果测量的反应。这些发现与之前的研究一致，表明THC及其代谢物是大麻的主要活性成分。他们还表明，神经生理EEG和ERP测量是THC作用的有用生物标志物。
This study investigated the contribution of different cannabinoids to the subjective, behavioral and neurophysiological effects of smoked marijuana. Healthy marijuana users 0 2 men, 11 women) participated in four sessions. They were randomly assigned to a low or a high Delta(9)-tetrahydrocannabinol group (THC; 1.8% versus 3.6%). In the four sessions under blinded conditions subjects smoked marijuana cigarettes containing placebo (no active cannabinoids), or cigarettes containing THC with low or high levels of cannabichromene (CBC; 0.1% versus 0.5%) and low or high levels of cannabidiol (CBD; 0.2% versus 1.0%). Dependent measures included subjective reports, measures of cognitive task performance and neurophysiological measures [electroencephalographic (EEG) and event-related potential (ERP)]. Compared to placebo, active THC cigarettes produced expected effects on mood, behavior and brain activity. A decrease in performance, reduction in EEG power and attenuation of ERP components reflecting attentional processes were observed during tests of working memory and episodic memory. Most of these effects were not dose-dependent. Varying the concentrations of CBC and CBD did not change subjects' responses on any of the outcome measures. These findings are consistent with previous studies indicating that THC and its metabolites are the primary active constituents of marijuana. They also suggest that neurophysiological EEG and ERP measures are useful biomarkers of the effects of THC.