Cardioprotective Effect of Licochalcone D against Myocardial Ischemia/Reperfusion Injury in Langendorff-Perfused Rat Hearts.
Cardioprotective Effect of Licochalcone D against Myocardial Ischemia/Reperfusion Injury in Langendorff-Perfused Rat Hearts.
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DOI：
10.1371/journal.pone.0128375
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发表时间：
2015
期刊：
影响因子：
3.7
通讯作者：
Li CG
中科院分区：
文献类型：
--
作者：
Yuan X;Niu HT;Wang PL;Lu J;Zhao H;Liu SH;Zheng QS;Li CG
香精是“功能性食品”的重要组成部分，对心血管功能具有有益作用。本研究旨在探讨甘草查尔酮D（LD）对心肌缺血/再灌注损伤的保护作用及其可能的机制。与I/R组相比，LD治疗可增强心肌功能（增加LVDP、dp/dt max、dp/dt min、HR和CR），减轻心肌损伤（降低LDH、CK和心肌梗死面积）。此外，LD治疗逆转了I/R诱导的caspase-3和PARP的裂解，导致I/R心肌组织中促炎因子的显著减少和抗氧化能力的增加。其抗凋亡、抗炎和抗氧化作用的机制与激活AKT通路、阻断NF-κB/p65和p38 MAPK通路有关。此外，LD治疗显着激活内皮型一氧化氮合酶（eNOS）和减少一氧化氮（NO）的生产。提示LD具有真实的心肌保护作用，为LD在心肌I/R损伤中的应用提供了依据。
Flavonoids are important components of ‘functional foods’, with beneficial effects on cardiovascular function. The present study was designed to investigate whether licochalcone D (LD) could be a cardioprotective agent in ischemia/reperfusion (I/R) injury and to shed light on its possible mechanism. Compared with the I/R group, LD treatment enhanced myocardial function (increased LVDP, dp/dt max, dp/dt min, HR and CR) and suppressed cardiac injury (decreased LDH, CK and myocardial infarct size). Moreover, LD treatment reversed the I/R-induced cleavage of caspase-3 and PARP, resulting in a significant decrease in proinflammatory factors and an increase in antioxidant capacity in I/R myocardial tissue. The mechanisms underlying the antiapoptosis, antiinflammation and antioxidant effects were related to the activation of the AKT pathway and to the blockage of the NF-κB/p65 and p38 MAPK pathways in the I/R-injured heart. Additionally, LD treatment markedly activated endothelial nitric oxide synthase (eNOS) and reduced nitric oxide (NO) production. The findings indicated that LD had real cardioprotective potential and provided support for the use of LD in myocardial I/R injury.
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DOI：
10.1016/0306-3623(93)90159-u
发表时间：
1993-07-01
期刊：
GENERAL PHARMACOLOGY-THE VASCULAR SYSTEM
影响因子：
--
作者：
DUARTE, J;VIZCAINO, FP;ZARZUELO, A
通讯作者：
ZARZUELO, A
DOI：
10.1161/01.atv.17.11.2744
发表时间：
1997-11-01
影响因子：
8.7
作者：
Hayek, T;Fuhrman, B;Aviram, M
通讯作者：
Aviram, M
影响因子：
3.1
作者：
Fang, Fang;Li, Dongye;Sun, Hong
通讯作者：
Sun, Hong
DOI：
10.1152/ajpheart.01072.2005
发表时间：
2006-05-01
影响因子：
4.8
作者：
Khan, M;Varadharaj, S;Kuppusamy, P
通讯作者：
Kuppusamy, P
影响因子：
20.1
作者：
Bowden, RA;Ding, ZM;Burns, AR
通讯作者：
Burns, AR