Lithium and tricyclic augmentation of fluoxetine treatment for resistant major depression: a double-blind, controlled study.
Lithium and tricyclic augmentation of fluoxetine treatment for resistant major depression: a double-blind, controlled study.
复制标题
锂盐和三环类药物增强氟西汀治疗顽固性重度抑郁症：一项双盲对照研究。
DOI：
10.1176/ajp.151.9.1372
复制
发表时间：
1994
期刊：
影响因子：
--
通讯作者：
Quitkin Fm
中科院分区：
文献类型：
--
作者：
M. Fava;J. Rosenbaum;McGrath Pj;Stewart Jw;J. Amsterdam;Quitkin Fm
41例对20 mg氟西汀治疗8周无效的患者被随机分配至3种治疗之一，持续4周：氟西汀40-60 mg/天，氟西汀20 mg/天+地昔帕明25-50 mg/天，氟西汀20 mg/天+锂300-600 mg/天。接受大剂量氟西汀治疗的患者（N = 15）明显优于氟西汀+锂剂治疗的患者（N = 14）和氟西汀+地昔帕明治疗的患者（N = 12）。在既往治疗的部分应答者中，高剂量氟西汀是最有效的治疗，但在无应答者中，高剂量氟西汀和氟西汀加锂剂是最有效的治疗。
Forty-one patients who had failed to respond to 8 weeks of treatment with 20 mg of fluoxetine were randomly assigned to one of three treatments for 4 weeks: 40-60 mg/day of fluoxetine, 20 mg/day of fluoxetine plus 25-50 mg/day of desipramine, and 20 mg/day of fluoxetine plus 300-600 mg/day of lithium. Patients treated with high-dose fluoxetine (N = 15) did significantly better than patients treated with fluoxetine plus lithium (N = 14) and those treated with fluoxetine plus desipramine (N = 12). High-dose fluoxetine was the most effective treatment among partial responders to previous treatment, but high-dose fluoxetine and fluoxetine plus lithium were the most effective treatments among nonresponders.