Atopic dermatitis as a risk factor for severe visual field loss in youth-a retrospective cohort study of glaucoma under steroid treatment
Atopic dermatitis as a risk factor for severe visual field loss in youth-a retrospective cohort study of glaucoma under steroid treatment
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特应性皮炎是青少年严重视野缺损的危险因素——类固醇治疗下青光眼的回顾性队列研究
DOI：
10.1007/s00417-020-04925-z
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发表时间：
2021
期刊：
影响因子：
--
通讯作者：
Tsujikawa A
中科院分区：
文献类型：
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作者：
Suda K;Akagi T;Ikeda HO;Kameda T;Hasegawa T;Miyake M;Kido A;Nakano E;Tsujikawa A
PurposeTo assess the characteristics of glaucoma patients who received systemic or topical steroids treatment.MethodsPatients who received steroid treatment were selected from total 4256 patients at our tertiary referral center of glaucoma management between August 2011 and October 2017.从临床记录中提取受试者的临床特征。为了评估影响最高眼压观察期间（最大眼压）或平均偏差（MD）的视野在第一次和最后一次访问的因素，单变量和多变量回归分析进行了广义estimating equation.Results382眼的196例患者被纳入本研究。最常见的疾病是特应性皮炎（58只眼），其次是自身免疫性疾病。与其他疾病患者相比，特应性皮炎患者明显更年轻（38.0 ± 11.2岁，p< 0.001），MD更低（首次访视时为− 9.3 ± 9.1 dB，p= 0.01;末次访视时为− 10.6 ± 9.2 dB，p= 0.004）。在多变量回归分析，年龄和MD在第一次访问，最大眼压，和特应性皮炎与MD在最后vision.ConclusionsThe结果本研究表明，特应性皮炎患者进行不可逆的视野损失的风险，即使在青年。为了早期发现高眼压，应建议在特应性皮炎的管理中加强眼科筛查。
PurposeTo assess the characteristics of glaucoma patients who received systemic or topical steroid treatment.MethodsPatients who received steroid treatment were selected from a total of 4256 patients at our tertiary referral center of glaucoma management between August 2011 and October 2017. Clinical characteristics of the subjects were extracted from clinical records. To evaluate the factors influencing highest intraocular pressure during observation (max-IOP) or mean deviations (MDs) of visual field at the first and last visits, univariate and multivariate regression analyses were performed using a generalized estimating equation.ResultsThree hundred and eighty-two eyes of 196 patients were included in this study. The most frequent disease as the reason for steroid treatment was atopic dermatitis (58 eyes) followed by autoimmune diseases. The patients with atopic dermatitis were significantly younger (38.0 ± 11.2 years old,p< 0.001) and had lower MD (− 9.3 ± 9.1 dB at first visit,p= 0.01; − 10.6 ± 9.2 dB at last visit,p= 0.004) than those with other diseases. In multivariate regression analysis, age and MD at first visit, max-IOP, and atopic dermatitis were correlated with MD at last visit.ConclusionsThe results of the present study suggest that patients with atopic dermatitis carry the risk of irreversible visual field loss even in youth. For earlier detection of high intraocular pressure, reinforcement of ophthalmological screening in management of atopic dermatitis should be recommended.