The berkeleyacetals, three meroterpenes from a deep water acid mine waste Penicillium
The berkeleyacetals, three meroterpenes from a deep water acid mine waste Penicillium
复制标题
DOI：
10.1021/np070329z
复制
发表时间：
2007-11-01
影响因子：
5.1
通讯作者：
Patacini, Brianna
中科院分区：
文献类型：
--
作者：
Stierle, Donald B.;Stierle, Andrea A.;Patacini, Brianna
伯克利坑湖是一个1500英尺深的废弃露天铜矿，充满了超过1140亿升的酸性，金属硫酸盐污染的水。这种恶劣的环境被证明是产生新型生物活性化合物的不寻常微生物的来源。我们最近报道了从伯克利坑湖的一种深水青霉菌中分离到的两种新的杂合聚酮-萜类代谢产物berkeleydione（1）和berkeleytrione（2）的结构。本文报道了从该菌的提取物中分离得到的三个新化合物，berkeleyacetals A-C（3-5）的结构。通过质谱和核磁共振数据与文献报道的小檗碱二酮（1）的结构比较，推测了这些化合物的结构。
Berkeley Pit Lake is a 1500 ft deep abandoned open-pit copper mine filled with over 1140 billion liters of acidic, metal-sulfate-contaminated water. This harsh environment is proving to be a source of unusual microorganisms that produce novel bioactive compounds. We recently reported the structures of berkeleydione (1) and berkeleytrione (2), two novel hybrid polyketide-terpenoid metabolites isolated from a deep water Penicillium sp. growing in Berkeley Pit Lake. In this paper we report the structures of three new compounds, berkeleyacetals A-C (3-5) isolated from extracts of this fungus. The structures of these compounds were deduced by comparison of mass spectral and NMR data to that of berkeleydione (1).