Combined multi-distance frequency domain and diffuse correlation spectroscopy system with simultaneous data acquisition and real-time analysis
Combined multi-distance frequency domain and diffuse correlation spectroscopy system with simultaneous data acquisition and real-time analysis
复制标题
DOI：
10.1364/boe.8.003993
复制
发表时间：
2017-09-01
影响因子：
3.4
通讯作者：
Franceschini, Maria Angela
中科院分区：
文献类型：
--
作者：
Carp, Stefan A.;Farzam, Parisa;Franceschini, Maria Angela
频域近红外光谱（FD-NIRS）和扩散相关光谱（DCS）已成为非侵入性评估组织健康的协同技术。结合FD-NIRS血氧测定法与DCS血流测量，可以量化组织氧代谢率，这是一个比单独使用NIRS或DCS估计值与基础生理学和病理学更密切相关的参数。在这里，我们描述了第一个商业上可用的集成仪器，称为“MetaOx”，旨在使同时FD-NIRS和DCS测量速率为10 + Hz，并提供实时数据评估。我们同时获得的表征数据证明性能等同于单个设备和样本在体内测量的脉动解决血流，前臂闭塞血流动力学变化和肌肉氧代谢率监测在固定自行车运动。(C)2017美国光学学会
Frequency domain near infrared spectroscopy (FD-NIRS) and diffuse correlation spectroscopy (DCS) have emerged as synergistic techniques for the non-invasive assessment of tissue health. Combining FD-NIRS oximetry with DCS measures of blood flow, the tissue oxygen metabolic rate can be quantified, a parameter more closely linked to underlying physiology and pathology than either NIRS or DCS estimates alone. Here we describe the first commercially available integrated instrument, called the "MetaOx", designed to enable simultaneous FD-NIRS and DCS measurements at rates of 10 + Hz, and offering real-time data evaluation. We show simultaneously acquired characterization data demonstrating performance equivalent to individual devices and sample in vivo measurements of pulsation resolved blood flow, forearm occlusion hemodynamic changes and muscle oxygen metabolic rate monitoring during stationary bike exercise. (C) 2017 Optical Society of America