Association Between Hormone Receptor Expression and Epidermal Growth Factor Receptor Mutation in Patients Operated on for Non-Small Cell Lung Cancer
Association Between Hormone Receptor Expression and Epidermal Growth Factor Receptor Mutation in Patients Operated on for Non-Small Cell Lung Cancer
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DOI：
10.1016/j.athoracsur.2011.02.001
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发表时间：
2011-05-01
影响因子：
4.6
通讯作者：
Wang, Si-yu
中科院分区：
文献类型：
--
作者：
Sun, Hai-bo;Zheng, Yan;Wang, Si-yu
背景。雌激素受体（ER）和孕激素受体（PR）在乳腺癌中发挥重要作用。同样，也有一些ER和PR在肺癌中表达的报道，但结果并不一致。本研究的目的是探讨非小细胞肺癌（NSCLC）中激素受体表达与临床病理因素和表皮生长因子受体（EGFR）突变之间的关联。方法。我们使用免疫组织化学方法评估了 316 例切除的 NSCLC 标本的 ER-α、PR、人表皮生长因子受体 2 和芳香酶 (n = 272) 的表达。通过聚合酶链式反应 (PCR) 评估 EGFR 突变。结果。所有患者中 ER-α 和 PR 的检测率分别为 36.1% 和 44.9%。 ER-α主要表达于细胞质(94.7%),PR主要表达于细胞核(95.8%)。 64.0%的患者细胞质中检测到芳香酶。 ER-α 表达与女性性别显着相关（p = 0.004）。 PR 的表达与更好的临床病理特征显着相关。 ER-α 表达与 PR（r = 0.275；p < 0.001）和芳香酶（r = 0.244；p < 0.001）表达水平呈正相关。 EGFR 突变与女性性别 (p = 0.001)、PR 阴性表达 (p < 0.001) 和芳香酶阴性表达 (p = 0.027) 独立相关。结论。 ER-α 和 PR 的表达区分了具有明确临床病理特征的 NSCLC 子集。 PR 和芳香酶的阴性表达与 EGFR 突变相关。 （Ann Thorac Surg 2011；91:1562-7） (C) 2011，胸外科医师协会
Background. Estrogen receptor (ER) and progesterone receptor (PR) play important roles in breast cancer. Similarly, there have been several reports of ER and PR expression in lung cancers, but the results have not been consistent. The aim of this study was to investigate the association between hormone receptor expression and clinicopathologic factors and epidermal growth factor receptor (EGFR) mutations in non-small cell lung cancer (NSCLC).Methods. We evaluated 316 resected NSCLC specimens for ER-alpha, PR, human epidermal growth factor receptor 2, and aromatase (n = 272) expression using immunohistochemical methods. EGFR mutations were evaluated with polymerase chain reaction (PCR).Results. ER-alpha and PR were detected in 36.1% and 44.9% of all patients, respectively. The expression of ER-alpha was observed mostly in cytoplasm (94.7%) and the expression of PR was observed mostly in nucleus (95.8%). Aromatase was detected in the cytoplasm of 64.0% of patients. ER-alpha expression was significantly associated with female gender (p = 0.004). The expression of PR was significantly associated with better clinicopathologic features. ER-alpha expression showed a positive correlation with PR (r = 0.275; p < 0.001) and aromatase (r = 0.244; p < 0.001) expression levels. EGFR mutation was independently associated with the female gender (p = 0.001), negative expression of PR (p < 0.001), and negative expression of aromatase (p = 0.027).Conclusions. The expression of ER-alpha and PR distinguish a subset of NSCLC that has defined clinicopathologic features. Negative expression of PR and aromatase correlate with EGFR mutation. (Ann Thorac Surg 2011;91:1562-7) (C) 2011 by The Society of Thoracic Surgeons