High dietary glycemic load and glycemic index increase risk of cardiovascular disease among middle-aged women - A population-based follow-up study
High dietary glycemic load and glycemic index increase risk of cardiovascular disease among middle-aged women - A population-based follow-up study
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DOI：
10.1016/j.jacc.2007.02.068
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发表时间：
2007-07-03
影响因子：
24
通讯作者：
van der Schouw, Yvonne T.
中科院分区：
文献类型：
--
作者：
Beulens, Joline W. J.;de Bruijne, Leonie M.;van der Schouw, Yvonne T.
目的 这项工作的目标是评估高膳食血糖负荷和血糖指数是否与心血管疾病 (CVD) 风险增加相关。 背景 膳食血糖指数和血糖负荷与 CVD 风险之间的关联尚未明确，特别是在食用适度血糖负荷饮食的人群中。此外，瘦和超重受试者之间的风险可能有所不同。方法在一个由 15,714 名 49 至 70 岁无糖尿病或 CVD 的荷兰女性组成的前瞻性队列中检查血糖指数和血糖负荷与 CVD 事件的关联。使用血糖生成指数、碳水化合物含量和单个食物的摄入频率来计算膳食血糖指数和血糖负荷。 结果 在9+/-2年的随访期间，发生了556例冠心病（CHD）和243例脑血管意外（CVA）。膳食血糖负荷（平均值 = 100；SD = 17）与 CVD 风险增加相关，根据 CVD 风险因素和饮食变量进行调整，最高四分位数与最低四分位数的风险比 (HR) 为 1.47（95% 置信区间 [CI] 1.04 至 2.09；p（趋势）= 0.03）。饮食血糖指数也观察到类似的结果，相应的 HR 为 1.33（95% CI 1.07 至 1.67；p（趋势）= 0.02）。血糖负荷往往与 CHD（HR 1.44；95% CI 0.95 至 2.19；p（趋势）= 0.14）和 CVA（HR 1.55；95% CI 0.81 至 2.97；p（趋势）= 0.10）相关，但血糖指数仅与 CHD 相关（HR 1.44；95% CI 1.10 至 1.89；p（趋势）= 0.01）。在超重女性（体重指数 > 25 kg/M2）中，血糖负荷与 CVD 相关（1.78；95% CI 1.11 至 2.85；p（趋势）= 0.04），但在正常体重女性中则不然（p（交互作用）= 0.19）。体重指数并没有改变血糖指数与 CVD 的关联。结论 在食用适度血糖负荷饮食的女性中，高膳食血糖负荷和血糖指数会增加 CVD 风险，特别是对于超重女性。
Objectives The goal of this work was to assess whether high dietary glycemic load and glycemic index are associated with an increased risk of cardiovascular disease (CVD).Background The associations of dietary glycemic index and glycemic load with risk of CVD are not well established, particularly in populations consuming modest glycemic load diets. Moreover, risk may differ between lean and overweight subjects.Methods Associations of glycemic index and glycemic load with incident CVD were examined in a prospective cohort of 15,714 Dutch women age 49 to 70 years without diabetes or CVD. Dietary glycemic index and glycemic load were calculated using the glycemic index, carbohydrate content, and frequency of intake of individual foods.Results During 9 +/- 2 years of follow-up, 556 cases of coronary heart disease (CHD) and 243 cases of cerebrovascular accident (CVA) occurred. Dietary glycemic load (mean = 100; SD = 17) was associated with increased risk of CVD, adjusted for CVD risk factors and dietary variables, with a hazard ratio (HR) for the highest against lowest quartile of 1.47 (95% confidence interval [CI] 1.04 to 2.09; p(trend) = 0.03). Similar results were observed for dietary glycemic index with a corresponding HR of 1.33 (95% CI 1.07 to 1.67; p(trend) = 0.02). Glycemic load tended to be associated with both CHD (HR 1.44; 95% CI 0.95 to 2.19; p(trend) = 0.14) and CVA (HR 1.55; 95% CI 0.81 to 2.97; p(trend) = 0.10), but glycemic index only with CHD (HR 1.44; 95% CI 1.10 to 1.89; p(trend) = 0.01). Among overweight women (body mass index > 25 kg/M2), glycemic load was associated with CVD (1.78; 95% CI 1.11 to 2.85; p(trend) = 0.04), but not among normal weight women (p(interaction) = 0.19). Body mass index did not modify the association of glycemic index with CVD.Conclusions Among women consuming modest glycemic load diets, high dietary glycemic load and glycemic index increase the risk of CVD, particularly for overweight women.