Reduced neuropeptide Y mRNA expression in the prefrontal cortex of subjects with bipolar disorder
Reduced neuropeptide Y mRNA expression in the prefrontal cortex of subjects with bipolar disorder
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DOI：
10.1097/00001756-199906030-00022
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发表时间：
1999-06-03
期刊：
影响因子：
1.7
通讯作者：
Hurd, YL
中科院分区：
文献类型：
--
作者：
Caberlotto, L;Hurd, YL
在本研究中，我们比较了被诊断为重度抑郁症、双相情感障碍和精神分裂症的受试者与无精神病史的正常对照者前额叶皮层（Brodmann区9和46）神经肽Y mRNA的表达水平。神经肽Y mRNA的表达与死亡间隔、年龄、性别、半球、自杀或酒精、大麻和可卡因/安非他明等物质的使用史没有相关性。唯一发现的显著改变与临床诊断有关；与对照组相比，双相情感障碍组神经肽Y mRNA表达减少。总的来说，目前的结果证实了神经肽Y参与情感障碍，并首次显示了NPY和双相情感障碍之间的特定关联。神经报告10:1747-1750 (C) 1999 Lippincott Williams & Wilkins。
IN the present study, we compared neuropeptide Y mRNA expression levels in the prefrontal cortex (Brodmann area 9 and 46) of subjects diagnosed with major depression, bipolar disorder and schizophrenia with those in normal controls without a psychiatric history. No correlation was found regarding neuropeptide Y mRNA expression and postmortem interval, age, gender, hemisphere side, suicide as cause of death, or the history of use of substances such as alcohol, marihuana and cocaine/amphetamine. The only significant alteration found was related to the clinical diagnosis; neuropeptide Y mRNA expression was reduced in the group of bipolar subjects as compared to the controls. Overall, the present results confirm an involvement of neuropeptide Y in affective disorders, and show for the first time a specific association between NPY and bipolar disorder. NeuroReport 10:1747-1750 (C) 1999 Lippincott Williams & Wilkins.