Tear film evaporation-Effect of age and gender
Tear film evaporation-Effect of age and gender
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DOI：
10.1016/j.clae.2010.03.002
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发表时间：
2010-08-01
影响因子：
3.2
通讯作者：
Maissa, Cecile
中科院分区：
文献类型：
--
作者：
Guillon, Michel;Maissa, Cecile
目的：干眼症在老年患者中更为常见，其中女性比男性更明显。传统上认为，随着年龄的增长，干眼症的增加与荷尔蒙变化导致的泪液分泌减少有关。老年患者（尤其是女性）脂质产生系统异常的临床证据已确立。因此，推测老年人群中更常见的干眼问题与蒸发有关。方法：使用俄勒冈健康科学大学蒸发仪在 30% 和 40% 湿度下测量泪膜蒸发。结果：160 名 45 岁以下的受试者和 57 名 45 岁或以上的受试者构成了研究人群。结果显示，年龄 (p < 0.001)、性别 (p < 0.001) 及其交互作用 (p < 0.001) 具有显着影响： (i) 在两种湿度下，老年组的蒸发率较高； (ii) 女性的蒸发率总体较高； (iii)年龄和性别的协同效应非常显着：老年女性的蒸发率比老年男性高34-80%，比年轻女性高36-69%。 结论：泪膜老化包括一个显着的蒸发成分，其特点是45岁以上的人比年轻人泪膜蒸发量更高。此外，在 45 岁以上的人群中，女性泪膜蒸发量显着高于男性。这些发现对于老花眼干眼症患者的治疗具有重要意义。 (C) 2010 年英国隐形眼镜协会。由爱思唯尔有限公司出版。保留所有权利。
Purpose: Dry eye is more prevalent in older patients and among them more marked in women than men. The increase in dry eye with aging is traditionally thought to be associated with a decrease in tear production enhanced by hormonal changes. Clinical evidence of an abnormal lipid production system in older patients, in particular women is established. It is therefore postulated that the greater prevalence of dry eye problems in an older population has an evaporative component.Methods: Tear film evaporation was measured with the Oregon Health Sciences University Evaporimeter at 30% and 40% humidity.Results: 160 subjects less than 45 years old and 57 subjects aged 45 years or more formed the study population. The results revealed a significant effect of age (p < 0.001), gender (p < 0.001) and their interaction (p < 0.001): (i) the rate of evaporation was higher in the older age group at both humidities; (ii) the rate of evaporation was overall higher for women; and (iii) the synergic effect of age and gender was very marked: the rate of evaporation of older women was 34-80% higher than that of older men and 36-69% than younger women.Conclusions: Aging of the tear film includes a significant evaporative component characterised by higher tear film evaporation for the over 45 compared to younger people. Further, in the over 45 years of age, a significantly greater tear film evaporation was recorded in women than men. The findings have significant implications for the management of presbyopic dry eye sufferers. (C) 2010 British Contact Lens Association. Published by Elsevier Ltd. All rights reserved.