LEACHING AND CYTOTOXICITY OF FORMALDEHYDE AND METHYL-METHACRYLATE FROM ACRYLIC RESIN DENTURE BASE MATERIALS
LEACHING AND CYTOTOXICITY OF FORMALDEHYDE AND METHYL-METHACRYLATE FROM ACRYLIC RESIN DENTURE BASE MATERIALS
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DOI：
10.1016/0022-3913(94)90448-0
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发表时间：
1994-06-01
影响因子：
4.6
通讯作者：
TAKAGI, N
中科院分区：
文献类型：
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作者：
TSUCHIYA, H;HOSHINO, Y;TAKAGI, N
丙烯酸树脂假牙有可能引起口腔粘膜刺激、炎症和过敏反应。对丙烯酸树脂中可浸出的物质、它们对培养细胞的细胞毒性以及减少其浸出的方法进行了系统的研究。在体内和体外条件下，甲醛和甲基丙烯酸甲酯显着浸入人唾液和唾液替代缓冲液中，尤其是自聚合树脂中。两种可浸出物质在其浸出浓度范围内均表现出潜在的细胞毒性。甲醛在低于甲基丙烯酸甲酯的浓度下具有细胞毒性。水中预浸降低了甲醛和甲基丙烯酸甲酯的后续浸出，并且降低的量取决于预浸温度的升高。建议在插入前将丙烯酸树脂假牙浸泡在热水 (50'C) 中，特别是对于用于复基或用作假牙基托材料的自聚合树脂，以最大程度地减少佩戴丙烯酸树脂假牙的患者发生不良反应的风险。
Acrylic resin dentures have the potential to elicit irritation, inflammation, and an allergic response of the oral mucosa. Studies of substances leachable from acrylic resins, their cytotoxicity to cultured cells, and means of reducing their leaching were systematically conducted. Under in vivo and in vitro conditions, formaldehyde and methyl methacrylate were significantly leached into human saliva and saliva-substitute buffer, especially from autopolymerized resins. Both leachable substances showed cytotoxic potentials in the range of their leaching concentrations. Formaldehyde was cytotoxic at lower concentrations than methyl methacrylate. Preleaching in water reduced subsequent leaching of both formaldehyde and methyl methacrylate, and the amount of reduction depended on an increase in the preleaching temperatures. Immersion of acrylic resin dentures in hot water (50' C) before insertion is recommended, especially for autopolymerized resins used either for rebasing or as denture base materials, to minimize the risk of adverse reactions in patients who wear acrylic resin dentures.