Motion opponency in visual cortex
Motion opponency in visual cortex
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DOI：
10.1523/jneurosci.19-16-07162.1999
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发表时间：
1999-08-15
影响因子：
5.3
通讯作者：
Newsome, WT
中科院分区：
文献类型：
--
作者：
Heeger, DJ;Boynton, GM;Newsome, WT
知觉研究表明，视觉运动知觉是由对手机制介导的，这些机制对应于对相反方向的运动敏感的相互抑制的神经元群体。我们使用功能性磁共振成像（fMRI）来测量人类视觉皮层的大脑活动，以测试运动顺应性的神经元相关性。在被称为人类MT复合体（MT+）的次级视觉皮层区域中存在强烈的运动重复性，但在初级视觉皮层中几乎没有运动重复性的证据。为了确定人和猴的耐受性水平是否相当，在猕猴脑的MT和MST区域中使用多单位电生理记录进行这些实验的变体。尽管记录部位之间的重复性程度存在显著差异，但猴和人数据的平均质量相似。这些结果提供了进一步的证据：（1）人类MT+反应的方向选择性信号，（2）人类MT+中的神经元信号支持视觉运动感知，（3）人类MT+与猕猴MT和邻近的运动敏感脑区同源，以及（4）fMRI测量与平均尖峰活动相关。
Perceptual studies suggest that visual motion perception is mediated by opponent mechanisms that correspond to mutually suppressive populations of neurons sensitive to motions in opposite directions. We tested for a neuronal correlate of motion opponency using functional magnetic resonance imaging (fMRI) to measure brain activity in human visual cortex. There was strong motion opponency in a secondary visual cortical area known as the human MT complex (MT+), but there was little evidence of motion opponency in primary visual cortex. To determine whether the level of opponency in human and monkey are comparable, a variant of these experiments was performed using multiunit electrophysiological recording in areas MT and MST of the macaque monkey brain. Although there was substantial variability in the degree of opponency between recording sites, the monkey and human data were qualitatively similar on average. These results provide further evidence that: (1) direction-selective signals underly human MT+ responses, (2) neuronal signals in human MT+ support visual motion perception, (3) human MT+ is homologous to macaque monkey MT and adjacent motion sensitive brain areas, and (4) that fMRI measurements are correlated with average spiking activity.