Increased prevalence of insulin resistance in women with a history of recurrent pregnancy loss
Increased prevalence of insulin resistance in women with a history of recurrent pregnancy loss
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DOI：
10.1016/s0015-0282(02)03247-8
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发表时间：
2002-09-01
影响因子：
6.7
通讯作者：
Kutteh, WH
中科院分区：
文献类型：
--
作者：
Craig, LB;Ke, RW;Kutteh, WH
目的：确定胰岛素抵抗是否与复发性妊娠丢失 (RPL) 相关。设计：单中心、病例对照、前瞻性研究。背景：大学相关生殖内分泌临床实践。患者：74 名患有 RPL 的非妊娠、非糖尿病女性。对照组为 74 名具有生育能力、未怀孕、无 RPL 的非糖尿病女性，她们至少有一个活产婴儿，并按年龄、种族和体重指数 (BMI) 进行匹配。干预措施：两组均同意获取空腹胰岛素和血糖水平。主要结果指标：胰岛素抵抗定义为空腹胰岛素水平 >20 muU/mL 或空腹血糖 胰岛素比例
Objective: To determine whether insulin resistance is associated with recurrent pregnancy loss (RPL).Design: Single center, case-controlled, prospective study.Setting: University-associated reproductive endocrinology clinical practice.Patient(s): Seventy-four nonpregnant, nondiabetic women with RPL. Controls were 74 fertile, nonpregnant, nondiabetic women without RPL who had at least one live infant, and were matched by age, race, and body mass index (BMI).Intervention(s): Both groups consented to obtaining fasting insulin and glucose levels.Main Outcome Measure(s): Insulin resistance was defined as a fasting insulin level >20 muU/mL or a fasting glucose to insulin ratio of